diethyl N-(2-phenylimidazo[1,2-a]pyridin-7-yl)aminomethylenemalonate

Base Information

• Chemical Name: diethyl N-(2-phenylimidazo[1,2-a]pyridin-7-yl)aminomethylenemalonate
• CAS No.: 1375111-03-7
• Molecular Formula: C₂₁H₂₁N₃O₄
• Molecular Weight: 379.415
• Mol file: 1375111-03-7.mol

Synonyms:diethyl N-(2-phenylimidazo[1,2-a]pyridin-7-yl)aminomethylenemalonate

Chemical Property of diethyl N-(2-phenylimidazo[1,2-a]pyridin-7-yl)aminomethylenemalonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl N-(2-phenylimidazo[1,2-a]pyridin-7-yl)aminomethylenemalonate

There total 7 articles about diethyl N-(2-phenylimidazo[1,2-a]pyridin-7-yl)aminomethylenemalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-phenylimidazo[1,2-a]pyridin-7-ylamine (1278407-54-7) + diethyl 2-ethoxymethylenemalonate (87-13-8) → diethyl N-(2-phenylimidazo[1,2-a]pyridin-7-yl)aminomethylenemalonate (1375111-03-7)

Guidance literature:

In toluene; for 21h; Reflux;

DOI:10.1016/j.ejmech.2012.03.011

Reference yield:

C14H9N5O → diethyl N-(2-phenylimidazo[1,2-a]pyridin-7-yl)aminomethylenemalonate (1375111-03-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Reflux

2: water; sodium hydroxide / 20 h / Reflux

3: toluene / 21 h / Reflux

With water; sodium hydroxide; In toluene;

DOI:10.1016/j.ejmech.2012.03.011

Reference yield:

ethyl (2-phenylimidazo[1,2-a]pyridin-7-yl)carbamate (1375110-95-4) → diethyl N-(2-phenylimidazo[1,2-a]pyridin-7-yl)aminomethylenemalonate (1375111-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: water; sodium hydroxide / 20 h / Reflux

2: toluene / 21 h / Reflux

With water; sodium hydroxide; In toluene;

DOI:10.1016/j.ejmech.2012.03.011

upstream raw materials:

2-amino-4-ethoxycarbonyl-pyridine

2-phenylimidazo[1,2-a]pyridin-7-ylamine

diethyl 2-ethoxymethylenemalonate

ethyl (2-phenylimidazo[1,2-a]pyridin-7-yl)carbamate