(E)-3-(1-(3-(4-tert-butylphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide

Base Information

Chemical Name:(E)-3-(1-(3-(4-tert-butylphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide
CAS No.:1257336-07-4
Molecular Formula:C₂₁H₂₆N₂O₃
Molecular Weight:354.449
Hs Code.:

Synonyms:(E)-3-(1-(3-(4-tert-butylphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide

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Chemical Property of (E)-3-(1-(3-(4-tert-butylphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide

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Technology Process of (E)-3-(1-(3-(4-tert-butylphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide

There total 3 articles about (E)-3-(1-(3-(4-tert-butylphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: (E)-methyl 3-(1-(3-(4-tert-butylphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)acrylate

: 1257336-07-4
(E)-3-(1-(3-(4-tert-butylphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide

Guidance literature:: With hydroxylamine potassium salt; In methanol; at 0 ℃; for 12h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b00062

Reference yield:

: 36404-89-4,32768-36-8
2-oxo-1,2-dihydro-pyridine-3-carbaldehyde

: 1257336-07-4
(E)-3-(1-(3-(4-tert-butylphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / Reflux

2: potassium carbonate / acetone / Reflux

3: hydroxylamine potassium salt / methanol / 12 h / 0 °C / Inert atmosphere

With hydroxylamine potassium salt; potassium carbonate; In methanol; dichloromethane; acetone; 1: |Wittig Olefination;
DOI:10.1021/acs.jmedchem.5b00062

Reference yield:

: [(E)-methyl 3-(2-oxo-1,2-dihydropyridin-3-yl)acrylate]

: 141499-24-3
4-(3-bromopropyl)-1-(1,1-dimethylethyl)benzene

: 1257336-07-4
(E)-3-(1-(3-(4-tert-butylphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux

2: hydroxylamine potassium salt / methanol / 12 h / 0 °C / Inert atmosphere

With hydroxylamine potassium salt; potassium carbonate; In methanol; acetone;
DOI:10.1021/acs.jmedchem.5b00062