4-(2-(2,2'-bipyridine-(8S,10S)-4,5-pineno-5'-ylethynyl)4-tert-butylphenyl)-2-methyl-but-3-yn-2-ol

Base Information

Chemical Name:4-(2-(2,2'-bipyridine-(8S,10S)-4,5-pineno-5'-ylethynyl)4-tert-butylphenyl)-2-methyl-but-3-yn-2-ol
CAS No.:1434147-20-2
Molecular Formula:C₃₄H₃₆N₂O
Molecular Weight:488.673
Hs Code.:

Synonyms:4-(2-(2,2'-bipyridine-(8S,10S)-4,5-pineno-5'-ylethynyl)4-tert-butylphenyl)-2-methyl-but-3-yn-2-ol

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Chemical Property of 4-(2-(2,2'-bipyridine-(8S,10S)-4,5-pineno-5'-ylethynyl)4-tert-butylphenyl)-2-methyl-but-3-yn-2-ol

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Technology Process of 4-(2-(2,2'-bipyridine-(8S,10S)-4,5-pineno-5'-ylethynyl)4-tert-butylphenyl)-2-methyl-but-3-yn-2-ol

There total 5 articles about 4-(2-(2,2'-bipyridine-(8S,10S)-4,5-pineno-5'-ylethynyl)4-tert-butylphenyl)-2-methyl-but-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1434147-19-9
(8S,10S)-4,5-pineno-5'-((5-tert-butyl-2-(trifuoromethylsulfonyl)phenyl)ethynyl)-2,2'-bipyridine

: 115-19-5
2-methyl-but-3-yn-2-ol

: 1434147-20-2
4-(2-(2,2'-bipyridine-(8S,10S)-4,5-pineno-5'-ylethynyl)4-tert-butylphenyl)-2-methyl-but-3-yn-2-ol

Guidance literature:: With copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 14h; Inert atmosphere;
DOI:10.1002/chem.201204216

Reference yield:

: 1434147-60-0
(8S,10S)-4,5-pineno-5'-bromo-2,2'-bipyridine

: 1434147-20-2
4-(2-(2,2'-bipyridine-(8S,10S)-4,5-pineno-5'-ylethynyl)4-tert-butylphenyl)-2-methyl-but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 12 h / 80 °C / Inert atmosphere

2: potassium carbonate / methanol; dichloromethane / 5 h / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

4: copper(l) iodide; diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 14 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling / 3: |Sonogashira Cross-Coupling / 4: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201204216

Reference yield:

: 1434147-17-7
(8S,10S)-4,5-pineno-5'-((trimethylsilyl)ethynyl)-2,2'-bipyridine

: 1434147-20-2
4-(2-(2,2'-bipyridine-(8S,10S)-4,5-pineno-5'-ylethynyl)4-tert-butylphenyl)-2-methyl-but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / methanol; dichloromethane / 5 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3: copper(l) iodide; diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 14 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling / 3: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201204216