₍S)-2-methyl-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)thiazole

Base Information

• Chemical Name: ₍S)-2-methyl-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)thiazole
• CAS No.: 1429557-66-3
• Molecular Formula: C₁₀H₁₃N₅S
• Molecular Weight: 235.313

Synonyms:₍S)-2-methyl-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)thiazole

Chemical Property of ₍S)-2-methyl-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)thiazole

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Technology Process of ₍S)-2-methyl-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)thiazole

There total 1 articles about ₍S)-2-methyl-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-methylthiazole-4-carboxylate (6436-59-5) → (S)-2-methyl-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)thiazole (1429557-66-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / 14 h / 20 °C / Inert atmosphere

2.1: methanol / 8 h / 60 - 70 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

With hydrazine hydrate; trifluoroacetic acid; In methanol; ethanol; dichloromethane;

DOI:10.1021/jm5017413

Reference yield: 41.0%

4-(thiophen-2-yl)benzoyl chloride + (S)-2-methyl-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)thiazole (1429557-66-3) → (S)-(8-methyl-3-(2-methylthiazol-4-yl)-5,6-dihydro-[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl)(4-(thiophen-2-yl)phenyl)methanone (1429560-58-6)

Guidance literature:

₍S)-2-methyl-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)thiazole; With 4-methyl-morpholine; In dichloromethane; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

4-(thiophen-2-yl)benzoyl chloride; In dichloromethane; at 0 - 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1021/jm5017413

upstream raw materials:

ethyl 2-methylthiazole-4-carboxylate

Downstream raw materials:

(S)-(8-methyl-3-(2-methylthiazol-4-yl)-5,6-dihydro-[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl)(4-(thiophen-2-yl)phenyl)methanone

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