3-{[3-(azidomethyl)-6-chloro-2-fluorophenyl]oxy}-2,5-dichlorobenzonitrile

Base Information

Chemical Name:3-{[3-(azidomethyl)-6-chloro-2-fluorophenyl]oxy}-2,5-dichlorobenzonitrile
CAS No.:1093262-30-6
Molecular Formula:C₁₄H₆Cl₃FN₄O
Molecular Weight:371.585
Hs Code.:

Synonyms:3-{[3-(azidomethyl)-6-chloro-2-fluorophenyl]oxy}-2,5-dichlorobenzonitrile

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Chemical Property of 3-{[3-(azidomethyl)-6-chloro-2-fluorophenyl]oxy}-2,5-dichlorobenzonitrile

Chemical Property:

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Technology Process of 3-{[3-(azidomethyl)-6-chloro-2-fluorophenyl]oxy}-2,5-dichlorobenzonitrile

There total 5 articles about 3-{[3-(azidomethyl)-6-chloro-2-fluorophenyl]oxy}-2,5-dichlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1093262-28-2
3-{[3-(bromomethyl)-6-chloro-2-fluorophenyl]oxy}-2,5-dichlorobenzonitrile

: 1093262-30-6
3-{[3-(azidomethyl)-6-chloro-2-fluorophenyl]oxy}-2,5-dichlorobenzonitrile

Guidance literature:: With sodium azide; In dimethyl sulfoxide; at 25 ℃;

Reference yield:

: 261762-91-8
6-chloro-2-fluoro-3-methylphenol

: 1093262-30-6
3-{[3-(azidomethyl)-6-chloro-2-fluorophenyl]oxy}-2,5-dichlorobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

1.2: 72 h / 110 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Reflux

4.1: sodium azide / dimethyl sulfoxide / 25 °C

With N-Bromosuccinimide; sodium azide; 18-crown-6 ether; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; dimethyl sulfoxide;

Reference yield:

: 202865-57-4
1-bromo-2,5-dichloro-3-fluorobenzene

: 1093262-30-6
3-{[3-(azidomethyl)-6-chloro-2-fluorophenyl]oxy}-2,5-dichlorobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

1.2: 72 h / 110 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Reflux

4.1: sodium azide / dimethyl sulfoxide / 25 °C

With N-Bromosuccinimide; sodium azide; 18-crown-6 ether; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; dimethyl sulfoxide;