2,3,6-trimethoxy-5-nitrophenethyl 5-chloro-2,4-dihydroxybenzoate

Base Information

• Chemical Name: 2,3,6-trimethoxy-5-nitrophenethyl 5-chloro-2,4-dihydroxybenzoate
• CAS No.: 913621-96-2
• Molecular Formula: C₁₈H₁₈ClNO₉
• Molecular Weight: 427.795
• Mol file: 913621-96-2.mol

Synonyms:2,3,6-trimethoxy-5-nitrophenethyl 5-chloro-2,4-dihydroxybenzoate

Chemical Property of 2,3,6-trimethoxy-5-nitrophenethyl 5-chloro-2,4-dihydroxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,6-trimethoxy-5-nitrophenethyl 5-chloro-2,4-dihydroxybenzoate

There total 3 articles about 2,3,6-trimethoxy-5-nitrophenethyl 5-chloro-2,4-dihydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-(2,3,6-trimethoxy-5-nitrophenyl)ethanol (884646-69-9) + 5-chloro-2,4-dihydroxy-benzoic acid (67828-44-8) → 2,3,6-trimethoxy-5-nitrophenethyl 5-chloro-2,4-dihydroxybenzoate (913621-96-2)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1021/jo061054f

Reference yield:

2-(2,3,6-trimethoxyphenyl)ethanol (913621-92-8) → 2,3,6-trimethoxy-5-nitrophenethyl 5-chloro-2,4-dihydroxybenzoate (913621-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: AcOH; aq. HNO₃ / 0.5 h / 60 °C

1.2: 53 percent / LiOH / H₂O; methanol; tetrahydrofuran / 3 h

2.1: 43 percent / PPh₃; DIAD / tetrahydrofuran / 12 h / 20 °C

With di-isopropyl azodicarboxylate; nitric acid; acetic acid; triphenylphosphine; In tetrahydrofuran;

DOI:10.1021/jo061054f

Reference yield:

1,2,4-trimethoxy-benzene (135-77-3) → 2,3,6-trimethoxy-5-nitrophenethyl 5-chloro-2,4-dihydroxybenzoate (913621-96-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-BuLi / diethyl ether / 2 h / Heating

1.2: 81 percent / diethyl ether / 2 h / Heating

2.1: AcOH; aq. HNO₃ / 0.5 h / 60 °C

2.2: 53 percent / LiOH / H₂O; methanol; tetrahydrofuran / 3 h

3.1: 43 percent / PPh₃; DIAD / tetrahydrofuran / 12 h / 20 °C

With n-butyllithium; di-isopropyl azodicarboxylate; nitric acid; acetic acid; triphenylphosphine; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo061054f

upstream raw materials:

2-(2,3,6-trimethoxy-5-nitrophenyl)ethanol

5-chloro-2,4-dihydroxy-benzoic acid

2-(2,3,6-trimethoxyphenyl)ethanol

1,2,4-trimethoxy-benzene

Downstream raw materials:

3-amino-2,5,6-trimethoxyphenethyl 5-chloro-2,4-dihydroxybenzoate