2-AMINO-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANOL HCL

Base Information

• Chemical Name: 2-AMINO-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANOL HCL
• CAS No.: 852392-18-8
• Molecular Formula: C₉H₁₀F₃NO₂
• Molecular Weight: 221.179
• Hs Code.: 2922500090
• Mol file: 852392-18-8.mol

Synonyms:2-amino-1-(3-trifluoromethoxy-phenyl)-ethanol

Chemical Property of 2-AMINO-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANOL HCL

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

α-(Aminomethyl)-3-(trifluoromethoxy)benzenemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: α-(Aminomethyl)-3-(trifluoromethoxy)benzenemethanol is used as a reagent in the synthesis of potent and selective ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase. It is also used as a reagent in the synthesis of 1-aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.

Technology Process of 2-AMINO-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANOL HCL

There total 2 articles about 2-AMINO-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANOL HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(trifluoromethoxy)benzaldehyde (52771-21-8,50823-91-1) → 2-amino-1-(3-trifluoromethoxy-phenyl)-ethanol (852392-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ZnI₂ / diethyl ether

2: LiAlH₄ / diethyl ether / Heating

With lithium aluminium tetrahydride; zinc(II) iodide; In diethyl ether;

DOI:10.1016/j.bmcl.2005.03.003

Reference yield:

(3-trifluoromethoxy-phenyl)-trimethylsilanyloxy-acetonitrile → 2-amino-1-(3-trifluoromethoxy-phenyl)-ethanol (852392-18-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Heating;

DOI:10.1016/j.bmcl.2005.03.003

Reference yield:

2-amino-1-(3-trifluoromethoxy-phenyl)-ethanol (852392-18-8) + 4-chloro-6-(3-chloro-4-trifluoromethylphenyl)-pyrimidine (954223-40-6) + trifluoroacetic acid (76-05-1) → 2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-[3-(trifluoromethoxy)phenyl]ethanol trifluoroacetate

Guidance literature:

2-amino-1-(3-trifluoromethoxy-phenyl)-ethanol; 4-chloro-6-(3-chloro-4-trifluoromethylphenyl)-pyrimidine; With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 100 ℃; for 20h; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;

upstream raw materials:

3-(trifluoromethoxy)benzaldehyde

Downstream raw materials:

2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-[3-(trifluoromethoxy)phenyl]ethanol

Refernces

• 1、 Jarvest, Richard L.,Erskine, Symon G.,Forrest, Andrew K.,Fosberry, Andrew P.,Hibbs, Martin J.,Jones, Joanna J.,O'Hanlon, Peter J.,Sheppard, Robert J.,Worby, Angela. "Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase". . p. 2305 - 2309. Retrieved 2007/10/03.