butyl 2-[(2-{(2R)-2-[(1E,3S)-4-(4'-chloro-3-biphenylyl)-3-hydroxy-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

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Chemical Name:butyl 2-[(2-{(2R)-2-[(1E,3S)-4-(4'-chloro-3-biphenylyl)-3-hydroxy-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate
CAS No.:1365178-00-2
Molecular Formula:C₃₀H₃₃ClN₂O₄S₂
Molecular Weight:585.188
Hs Code.:

Synonyms:butyl 2-[(2-{(2R)-2-[(1E,3S)-4-(4'-chloro-3-biphenylyl)-3-hydroxy-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

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Chemical Property of butyl 2-[(2-{(2R)-2-[(1E,3S)-4-(4'-chloro-3-biphenylyl)-3-hydroxy-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

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Technology Process of butyl 2-[(2-{(2R)-2-[(1E,3S)-4-(4'-chloro-3-biphenylyl)-3-hydroxy-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

There total 1 articles about butyl 2-[(2-{(2R)-2-[(1E,3S)-4-(4'-chloro-3-biphenylyl)-3-hydroxy-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₁ClN₂O₄S₂

: 1365178-00-2
butyl 2-[(2-{(2R)-2-[(1E,3S)-4-(4'-chloro-3-biphenylyl)-3-hydroxy-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

Guidance literature:: With borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at 20 ℃; for 0.416667h; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.bmc.2012.02.018

Reference yield: 83.0%

: 1365178-00-2
butyl 2-[(2-{(2R)-2-[(1E,3S)-4-(4'-chloro-3-biphenylyl)-3-hydroxy-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

: 494224-09-8
2-[(2-{(2R)-2-[(1E,3S)-4-(4'-chloro-1,1'-biphenyl-3-yl)-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid

Guidance literature:: butyl 2-[(2-{(2R)-2-[(1E,3S)-4-(4'-chloro-3-biphenylyl)-3-hydroxy-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate; With sodium hydroxide; In 1,2-dimethoxyethane; at 20 ℃; for 2h;

With hydrogenchloride; In 1,2-dimethoxyethane; water;
DOI:10.1016/j.bmc.2012.02.018