methyl 6-[({3-[(1-methylethyl)oxy]-5-[(phenylmethyl)oxy]phenyl}carbonyl)amino]pyridine-3-carboxylate

Base Information

Chemical Name:methyl 6-[({3-[(1-methylethyl)oxy]-5-[(phenylmethyl)oxy]phenyl}carbonyl)amino]pyridine-3-carboxylate
CAS No.:480464-65-1
Molecular Formula:C₂₄H₂₄N₂O₅
Molecular Weight:420.465
Hs Code.:

Synonyms:methyl 6-[({3-[(1-methylethyl)oxy]-5-[(phenylmethyl)oxy]phenyl}carbonyl)amino]pyridine-3-carboxylate

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Chemical Property of methyl 6-[({3-[(1-methylethyl)oxy]-5-[(phenylmethyl)oxy]phenyl}carbonyl)amino]pyridine-3-carboxylate

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Technology Process of methyl 6-[({3-[(1-methylethyl)oxy]-5-[(phenylmethyl)oxy]phenyl}carbonyl)amino]pyridine-3-carboxylate

There total 5 articles about methyl 6-[({3-[(1-methylethyl)oxy]-5-[(phenylmethyl)oxy]phenyl}carbonyl)amino]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 852520-53-7
3-benzyloxy-5-isopropoxybenzoic acid

: 36052-24-1
methyl 6-aminonicotinoate

: 480464-65-1
methyl 6-[({3-[(1-methylethyl)oxy]-5-[(phenylmethyl)oxy]phenyl}carbonyl)amino]pyridine-3-carboxylate

Guidance literature:: 3-benzyloxy-5-isopropoxybenzoic acid; With oxalyl dichloride; In DMF (N,N-dimethyl-formamide); dichloromethane; for 4h;

In diethyl ether; for 1h;

methyl 6-aminonicotinoate; In tetrahydrofuran; pyridine;

Reference yield:

: 852520-42-4
methyl 3-[(1-methylethyl)oxy]-5-[(phenylmethyl)oxy]benzoate

: 480464-65-1
methyl 6-[({3-[(1-methylethyl)oxy]-5-[(phenylmethyl)oxy]phenyl}carbonyl)amino]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / aq. NaOH / tetrahydrofuran

2: (COCl)2; DMF / CH₂Cl₂

3: pyridine / tetrahydrofuran

With pyridine; sodium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.01.087

Reference yield:

: 852520-53-7
3-benzyloxy-5-isopropoxybenzoic acid

: 480464-65-1
methyl 6-[({3-[(1-methylethyl)oxy]-5-[(phenylmethyl)oxy]phenyl}carbonyl)amino]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2; DMF / CH₂Cl₂

2: pyridine / tetrahydrofuran

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.01.087