2-(benzoyl-{1-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperidin-4-yl}-amino)-4-methylsulfanyl-butyric acid methyl ester

Base Information

Chemical Name:2-(benzoyl-{1-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperidin-4-yl}-amino)-4-methylsulfanyl-butyric acid methyl ester
CAS No.:833490-42-9
Molecular Formula:C₃₀H₃₅N₅O₃S
Molecular Weight:545.706
Hs Code.:

2-(benzoyl-{1-[3-(4-cyano-benzyl)-3<i>H</i>-imidazol-4-ylmethyl]-piperidin-4-yl}-amino)-4-methylsulfanyl-butyric acid methyl ester

Synonyms:2-(benzoyl-{1-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperidin-4-yl}-amino)-4-methylsulfanyl-butyric acid methyl ester

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Chemical Property of 2-(benzoyl-{1-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperidin-4-yl}-amino)-4-methylsulfanyl-butyric acid methyl ester

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Technology Process of 2-(benzoyl-{1-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperidin-4-yl}-amino)-4-methylsulfanyl-butyric acid methyl ester

There total 7 articles about 2-(benzoyl-{1-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperidin-4-yl}-amino)-4-methylsulfanyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 183500-37-0
4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile

: methyl N-benzoyl-N-(piperidin-4-yl)-(S)-methioninate hydrochloride

: 833490-42-9
2-(benzoyl-{1-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperidin-4-yl}-amino)-4-methylsulfanyl-butyric acid methyl ester

Guidance literature:: 4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile; methyl N-benzoyl-N-(piperidin-4-yl)-(S)-methioninate hydrochloride; With 3 A molecular sieve; triethylamine; In methanol; at 50 ℃; for 4h;

With sodium cyanoborohydride; In methanol; for 18h;
DOI:10.1021/jm030502y

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 833490-42-9
2-(benzoyl-{1-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperidin-4-yl}-amino)-4-methylsulfanyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 75 percent / aq. DIEA / dioxane / 24 h / 20 °C

2.1: triethylamine; NaBH₃CN / methanol / 48 h / 50 °C

3.1: triethylamine / CH₂Cl₂ / 24 h / 0 °C

4.1: 95 percent / HCl / methanol / 18 h / 20 °C

5.1: triethylamine / methanol

5.2: NaBH₃CN / methanol / 18 h / 50 °C

With hydrogenchloride; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1248/cpb.53.1324

Reference yield:

: 183500-36-9
4-(5-hydroxymethyl-imidazol-1-ylmethyl)-benzonitrile

: 833490-42-9
2-(benzoyl-{1-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperidin-4-yl}-amino)-4-methylsulfanyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: MnO₂ / dioxane / 3 h / 30 - 40 °C

2.1: triethylamine / methanol

2.2: NaBH₃CN / methanol / 18 h / 50 °C

With manganese(IV) oxide; triethylamine; In 1,4-dioxane; methanol;
DOI:10.1248/cpb.53.1324