(S)-methyl 3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)butanoate

Base Information

Chemical Name:(S)-methyl 3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)butanoate
CAS No.:1194044-31-9
Molecular Formula:C₁₅H₂₀BrF₂NO₃S
Molecular Weight:412.296
Hs Code.:

Synonyms:(S)-methyl 3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)butanoate

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Chemical Property of (S)-methyl 3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)butanoate

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Technology Process of (S)-methyl 3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)butanoate

There total 4 articles about (S)-methyl 3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 79-20-9
acetic acid methyl ester

: 1346145-52-5
(R,E)-N-(1-(5-bromo-2,4-difluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1194044-31-9
(S)-methyl 3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)butanoate

Guidance literature:: acetic acid methyl ester; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃;

With triisopropoxytitanium(IV) chloride; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

(R,E)-N-(1-(5-bromo-2,4-difluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; hexane; at -78 ℃; for 3h;

Reference yield: 72.0%

: 79-20-9
acetic acid methyl ester

: 2-methyl-propane-2-sulfinic acid [1-(3-bromo-phenyl)-ethylidene]-amide

: 1194044-31-9
(S)-methyl 3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)butanoate

Guidance literature:: acetic acid methyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃;

With triisopropoxytitanium(IV) chloride; In tetrahydrofuran; hexane; at -78 ℃;

2-methyl-propane-2-sulfinic acid [1-(3-bromo-phenyl)-ethylidene]-amide; In tetrahydrofuran; hexane; at -78 ℃;

Reference yield: 72.0%

: 79-20-9
acetic acid methyl ester

: 1194044-22-8
(R)-2-methyl-propane-2-sulfinic acid [1-(5-bromo-2,4-difluoro-phenyl)-ethylidene]-amide

: 1194044-31-9
(S)-methyl 3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)butanoate

Guidance literature:: With triisopropoxytitanium(IV) chloride; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; diastereoselective reaction;
DOI:10.1016/j.tetlet.2014.02.053