(S)-tert-butyl 3-((6-(2-chloro-4-methylphenyl)-2-(3,4-difluorobenzylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

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Chemical Name:(S)-tert-butyl 3-((6-(2-chloro-4-methylphenyl)-2-(3,4-difluorobenzylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate
CAS No.:1190707-52-8
Molecular Formula:C₃₁H₃₄ClF₂N₅O₂
Molecular Weight:582.093
Hs Code.:

Synonyms:(S)-tert-butyl 3-((6-(2-chloro-4-methylphenyl)-2-(3,4-difluorobenzylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 3-((6-(2-chloro-4-methylphenyl)-2-(3,4-difluorobenzylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

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Technology Process of (S)-tert-butyl 3-((6-(2-chloro-4-methylphenyl)-2-(3,4-difluorobenzylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

There total 6 articles about (S)-tert-butyl 3-((6-(2-chloro-4-methylphenyl)-2-(3,4-difluorobenzylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1190707-51-7
(S)-tert-butyl 3-((2-chloro-6-(2-chloro-4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

: 72235-53-1
3,4-difluorobenzylamine

: 1190707-52-8
(S)-tert-butyl 3-((6-(2-chloro-4-methylphenyl)-2-(3,4-difluorobenzylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 4h; Microwave irradiation;

Reference yield:

: 1190707-50-6
[(2-chloro-4-methylphenyl)ethynyl]trimethylsilane

: 1190707-52-8
(S)-tert-butyl 3-((6-(2-chloro-4-methylphenyl)-2-(3,4-difluorobenzylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 100 °C / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 4 h / 150 °C / Microwave irradiation

With potassium tert-butylate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 1190707-12-0
(S)-tert-butyl 3-((2-chloro-5-iodopyrimidin-4-ylamino)methyl)piperidine-1-carboxylate

: 1190707-52-8
(S)-tert-butyl 3-((6-(2-chloro-4-methylphenyl)-2-(3,4-difluorobenzylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 100 °C / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 4 h / 150 °C / Microwave irradiation

With potassium tert-butylate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;