3-methoxy-17α-[3'-(3,5-dichloro-2,4,6-trimethoxy)phenylisoxazol-5'-yl]estra-1,3,5(10)-trien-17β-ol

Base Information

Chemical Name:3-methoxy-17α-[3'-(3,5-dichloro-2,4,6-trimethoxy)phenylisoxazol-5'-yl]estra-1,3,5(10)-trien-17β-ol
CAS No.:1399860-66-2
Molecular Formula:C₃₁H₃₅Cl₂NO₆
Molecular Weight:588.528
Hs Code.:

Synonyms:3-methoxy-17α-[3'-(3,5-dichloro-2,4,6-trimethoxy)phenylisoxazol-5'-yl]estra-1,3,5(10)-trien-17β-ol

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Chemical Property of 3-methoxy-17α-[3'-(3,5-dichloro-2,4,6-trimethoxy)phenylisoxazol-5'-yl]estra-1,3,5(10)-trien-17β-ol

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Technology Process of 3-methoxy-17α-[3'-(3,5-dichloro-2,4,6-trimethoxy)phenylisoxazol-5'-yl]estra-1,3,5(10)-trien-17β-ol

There total 3 articles about 3-methoxy-17α-[3'-(3,5-dichloro-2,4,6-trimethoxy)phenylisoxazol-5'-yl]estra-1,3,5(10)-trien-17β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1399860-83-3
N-hydroxy-3,5-dichloro-2,4,6-trimethoxybenzenecarboximidoyl chloride

: 72-33-3
mestranol

: 1399860-66-2
3-methoxy-17α-[3'-(3,5-dichloro-2,4,6-trimethoxy)phenylisoxazol-5'-yl]estra-1,3,5(10)-trien-17β-ol

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In toluene; for 4h; regioselective reaction; Reflux;
DOI:10.1016/j.steroids.2012.05.003

Reference yield:

: 99421-66-6
2,4-dichloro-1,3,5-trimethoxybenzene

: 1399860-66-2
3-methoxy-17α-[3'-(3,5-dichloro-2,4,6-trimethoxy)phenylisoxazol-5'-yl]estra-1,3,5(10)-trien-17β-ol

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride

2: N-chloro-succinimide

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 4 h / Reflux

With N-chloro-succinimide; copper(l) iodide; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In toluene;
DOI:10.1016/j.steroids.2012.05.003

Reference yield:

: 99071-12-2
C₁₀H₁₁Cl₂NO₄

: 1399860-66-2
3-methoxy-17α-[3'-(3,5-dichloro-2,4,6-trimethoxy)phenylisoxazol-5'-yl]estra-1,3,5(10)-trien-17β-ol

Guidance literature:: Multi-step reaction with 2 steps

1: N-chloro-succinimide

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 4 h / Reflux

With N-chloro-succinimide; copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In toluene;
DOI:10.1016/j.steroids.2012.05.003