propenoic acid (1R)-(1R*,2S*)-2-(4-methoxybenzyloxy)-1,2-diphenylethyl ester

Base Information

• Chemical Name: propenoic acid (1R)-(1R*,2S*)-2-(4-methoxybenzyloxy)-1,2-diphenylethyl ester
• CAS No.: 1237738-29-2
• Molecular Formula: C₂₅H₂₄O₄
• Molecular Weight: 388.463
• Mol file: 1237738-29-2.mol

Synonyms:propenoic acid (1R)-(1R*,2S*)-2-(4-methoxybenzyloxy)-1,2-diphenylethyl ester

Chemical Property of propenoic acid (1R)-(1R*,2S*)-2-(4-methoxybenzyloxy)-1,2-diphenylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of propenoic acid (1R)-(1R*,2S*)-2-(4-methoxybenzyloxy)-1,2-diphenylethyl ester

There total 1 articles about propenoic acid (1R)-(1R*,2S*)-2-(4-methoxybenzyloxy)-1,2-diphenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(1R)-(1R*,2S*)-2-(4-methoxybenzyloxy)-1,2-diphenylethanol (1237738-28-1) + acryloyl chloride (814-68-6,25189-84-8) → propenoic acid (1R)-(1R*,2S*)-2-(4-methoxybenzyloxy)-1,2-diphenylethyl ester (1237738-29-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Cooling with ice/salt bath; Inert atmosphere;

DOI:10.1016/j.tetasy.2010.04.010

Reference yield:

propenoic acid (1R)-(1R*,2S*)-2-(4-methoxybenzyloxy)-1,2-diphenylethyl ester (1237738-29-2) + N-benzyliden-α-phenyl-glycine methyl ester (67627-99-0) → (2R,4S,5R)-2,5-diphenylpyrrolidine-2,4-dicarboxylic acid 4-[(1R,2S)-2-(4-methoxybenzyloxy)-1,2-diphenylethyl] ester 2-methyl ester (1237738-31-6) + (2S,4R,5S)-2,5-diphenylpyrrolidine-2,4-dicarboxylic acid 4-[(1R,2S)-2-(4-methoxybenzyloxy)-1,2-diphenylethyl] ester 2-methyl ester

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium bromide; In tetrahydrofuran; at 20 ℃; for 3h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2010.04.010

upstream raw materials:

(1R)-(1R*,2S*)-2-(4-methoxybenzyloxy)-1,2-diphenylethanol

acryloyl chloride

Downstream raw materials:

(2R,4S,5R)-2,5-diphenylpyrrolidine-2,4-dicarboxylic acid 4-[(1R,2S)-2-(4-methoxybenzyloxy)-1,2-diphenylethyl] ester 2-methyl ester