(Z)-N-[(2-azidophenyl)ethynyl]-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide

Base Information

Chemical Name:(Z)-N-[(2-azidophenyl)ethynyl]-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide
CAS No.:1610967-13-9
Molecular Formula:C₂₇H₂₈N₄O₂SSi
Molecular Weight:500.696
Hs Code.:

Synonyms:(Z)-N-[(2-azidophenyl)ethynyl]-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide

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Chemical Property of (Z)-N-[(2-azidophenyl)ethynyl]-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide

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Technology Process of (Z)-N-[(2-azidophenyl)ethynyl]-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide

There total 5 articles about (Z)-N-[(2-azidophenyl)ethynyl]-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1610967-50-4
1-[(2-azidophenyl)ethynyl]-5-nitro-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

: 1610967-57-1
(Z)-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide

: 1610967-13-9
(Z)-N-[(2-azidophenyl)ethynyl]-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide

Guidance literature:: With potassium phosphate; copper(l) iodide; In tetrahydrofuran; at 50 ℃; for 3h;
DOI:10.1021/ol5012604

Reference yield:

: 210880-58-3
[(2-azidophenyl)ethynyl]trimethylsilane

: 1610967-13-9
(Z)-N-[(2-azidophenyl)ethynyl]-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: copper(l) iodide; potassium phosphate / tetrahydrofuran / 3 h / 50 °C

With potassium phosphate; copper(l) iodide; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol5012604

Reference yield:

: 167558-54-5
2-(2,2-dibromo-vinyl)-phenylamine

: 1610967-13-9
(Z)-N-[(2-azidophenyl)ethynyl]-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / tetrahydrofuran / 9 h / 0 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride / dichloromethane / 18 h / Inert atmosphere

2.2: 3 h / Inert atmosphere

3.1: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

4.1: copper(l) iodide; potassium phosphate / tetrahydrofuran / 3 h / 50 °C

With pyridine; potassium phosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); tri-n-butyl-tin hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol5012604