benzyl N₂,N₂,N₆,N₆-tetra(Boc)-2,6-diaminopurin-9-ylacetate

Base Information

• Chemical Name: benzyl N₂,N₂,N₆,N₆-tetra(Boc)-2,6-diaminopurin-9-ylacetate
• CAS No.: 1354832-41-9
• Molecular Formula: C₃₄H₄₆N₆O₁₀
• Molecular Weight: 698.773
• Mol file: 1354832-41-9.mol

Synonyms:benzyl N₂,N₂,N₆,N₆-tetra(Boc)-2,6-diaminopurin-9-ylacetate

Chemical Property of benzyl N₂,N₂,N₆,N₆-tetra(Boc)-2,6-diaminopurin-9-ylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl N₂,N₂,N₆,N₆-tetra(Boc)-2,6-diaminopurin-9-ylacetate

There total 4 articles about benzyl N₂,N₂,N₆,N₆-tetra(Boc)-2,6-diaminopurin-9-ylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N2,N2,N6,N6-tetra(Boc)-2,6-diamino-9H-purine (1354832-40-8) + Benzyl bromoacetate (5437-45-6) → benzyl N2,N2,N6,N6-tetra(Boc)-2,6-diaminopurin-9-ylacetate (1354832-41-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 18.25h;

DOI:10.1039/c1ob06582c

Reference yield:

9,N2,N2,N6,N6-penta(Boc)-2,6-diaminopurine (1354832-39-5) → benzyl N2,N2,N6,N6-tetra(Boc)-2,6-diaminopurin-9-ylacetate (1354832-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: water; sodium hydrogencarbonate / methanol / 19 h / 20 - 50 °C

2: potassium carbonate / N,N-dimethyl-formamide / 18.25 h / 0 - 20 °C

With water; sodium hydrogencarbonate; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1039/c1ob06582c

Reference yield:

2,6-diaminopurine (1904-98-9) → benzyl N2,N2,N6,N6-tetra(Boc)-2,6-diaminopurin-9-ylacetate (1354832-41-9)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap / tetrahydrofuran / 18.08 h / 0 - 20 °C

2: water; sodium hydrogencarbonate / methanol / 19 h / 20 - 50 °C

3: potassium carbonate / N,N-dimethyl-formamide / 18.25 h / 0 - 20 °C

With dmap; water; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1039/c1ob06582c

upstream raw materials:

9,N₂,N₂,N₆,N₆-penta(Boc)-2,6-diaminopurine

N₂,N₂,N₆,N₆-tetra(Boc)-2,6-diamino-9H-purine

Benzyl bromoacetate

di-tert-butyl dicarbonate

Downstream raw materials:

N₂,N₂,N₆,N₆-tetra(Boc)-2,6-diaminopurin-9-ylacetic acid