methyl 1-(4-chloro-2-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

Base Information

Chemical Name:methyl 1-(4-chloro-2-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate
CAS No.:1418717-86-8
Molecular Formula:C₂₄H₂₀ClFN₂O₂
Molecular Weight:422.886
Hs Code.:

Synonyms:methyl 1-(4-chloro-2-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

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Chemical Property of methyl 1-(4-chloro-2-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

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Technology Process of methyl 1-(4-chloro-2-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

There total 6 articles about methyl 1-(4-chloro-2-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.2%

: 1418717-56-2
methyl 6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

: 71916-82-0
1-(bromomethyl)-4-chloro-2-fluorobenzene

: 1418717-86-8
methyl 1-(4-chloro-2-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 65 ℃; under 760.051 Torr;

Reference yield:

: 1418717-47-1
3-ethyl 5-methyl 2-amino-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate

: 1418717-86-8
methyl 1-(4-chloro-2-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1 h / 0 °C / 760.05 Torr

2: pyridinium chlorochromate / dichloromethane / 24 h / 20 °C / 760.05 Torr

3: caesium carbonate / methanol; hexane / 1 h / 60 °C / 760.05 Torr

4: caesium carbonate / N,N-dimethyl-formamide / 65 °C / 760.05 Torr

With caesium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1418717-44-8
3-ethyl 5-methyl 2-amino-6-methyl-4-(p-tolyl)-1,4-dihydropyridine-3,5-dicarboxylate

: 1418717-86-8
methyl 1-(4-chloro-2-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1.5 h / 20 °C / 760.05 Torr

2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1 h / 0 °C / 760.05 Torr

3: pyridinium chlorochromate / dichloromethane / 24 h / 20 °C / 760.05 Torr

4: caesium carbonate / methanol; hexane / 1 h / 60 °C / 760.05 Torr

5: caesium carbonate / N,N-dimethyl-formamide / 65 °C / 760.05 Torr

With caesium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;