NH₂-VFM-OMe

Base Information

• Chemical Name: NH₂-VFM-OMe
• CAS No.: 158022-24-3
• Molecular Formula: C₂₀H₃₁N₃O₄S
• Molecular Weight: 409.55
• Mol file: 158022-24-3.mol

Synonyms:NH₂-VFM-OMe

Chemical Property of NH₂-VFM-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of NH₂-VFM-OMe

There total 5 articles about NH₂-VFM-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-valinyl-phenylalaninyl-methionine methyl ester (959162-66-4) → NH2-VFM-OMe (158022-24-3)

Guidance literature:

With hydrogenchloride; methoxybenzene; In 1,4-dioxane; dichloromethane; 1) 0 deg C, 15 min, 2) r.t., 1 h;

DOI:10.1016/S0223-5234(98)80031-7

Reference yield:

t-Boc-L-valine (13734-41-3) → NH2-VFM-OMe (158022-24-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-ethyl-3-<3-(N,N-dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) r.t., overnight

2: H₂ / 10percent Pd-C / methanol / 760 Torr

3: 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, iPr₂NEt, 1-hydroxybenzotriazole / dimethylformamide / 16 h / Ambient temperature

4: HCl, anisole / dioxane; CH₂Cl₂ / 1) 0 deg C, 15 min, 2) r.t., 1 h

With hydrogenchloride; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(98)80031-7

Reference yield:

L-phenylalanine benzyl ester hydrochloride (2462-32-0) → NH2-VFM-OMe (158022-24-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-ethyl-3-<3-(N,N-dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) r.t., overnight

2: H₂ / 10percent Pd-C / methanol / 760 Torr

3: 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, iPr₂NEt, 1-hydroxybenzotriazole / dimethylformamide / 16 h / Ambient temperature

4: HCl, anisole / dioxane; CH₂Cl₂ / 1) 0 deg C, 15 min, 2) r.t., 1 h

With hydrogenchloride; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(98)80031-7

upstream raw materials:

Boc-valinyl-phenylalaninyl-methionine methyl ester

t-Boc-L-valine

L-phenylalanine benzyl ester hydrochloride

N-tert-butyloxycarbonyl-L-valyl-L-phenylalanine

Downstream raw materials:

(S)-2-{(S)-2-[(S)-2-(5-Chloro-2-hydroxy-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester

(S)-2-{(S)-2-[(S)-2-(3-Hydroxy-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester

C₃₆H₅₃N₅O₈S

C₃₆H₅₃N₅O₈S