3,5-bis-benzyloxy-4-[(2-benzyloxy-phenyl)-hydroxy-methyl]-benzoic acid tert-butyl ester

Base Information

• Chemical Name: 3,5-bis-benzyloxy-4-[(2-benzyloxy-phenyl)-hydroxy-methyl]-benzoic acid tert-butyl ester
• CAS No.: 1027522-99-1
• Molecular Formula: C₃₉H₃₈O₆
• Molecular Weight: 602.727
• Mol file: 1027522-99-1.mol

Synonyms:3,5-bis-benzyloxy-4-[(2-benzyloxy-phenyl)-hydroxy-methyl]-benzoic acid tert-butyl ester

Chemical Property of 3,5-bis-benzyloxy-4-[(2-benzyloxy-phenyl)-hydroxy-methyl]-benzoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-bis-benzyloxy-4-[(2-benzyloxy-phenyl)-hydroxy-methyl]-benzoic acid tert-butyl ester

There total 1 articles about 3,5-bis-benzyloxy-4-[(2-benzyloxy-phenyl)-hydroxy-methyl]-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

3,5-dibenzyloxy-4-bromobenzoic acid tert-butyl ester (158980-57-5) + 2-(phenylmethoxy)benzaldehyde (5896-17-3) → 3,5-bis-benzyloxy-4-[(2-benzyloxy-phenyl)-hydroxy-methyl]-benzoic acid tert-butyl ester (1027522-99-1)

Guidance literature:

3,5-dibenzyloxy-4-bromobenzoic acid tert-butyl ester; With n-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.333333h;

2-(phenylmethoxy)benzaldehyde; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.5h; Further stages.;

DOI:10.1021/jm020018f

Reference yield:

3,5-bis-benzyloxy-4-[(2-benzyloxy-phenyl)-hydroxy-methyl]-benzoic acid tert-butyl ester (1027522-99-1) → 3,5-bis-benzyloxy-4-(2-benzyloxy-benzoyl)-benzoic acid tert-butyl ester

Guidance literature:

With chromium(VI) oxide; sulfuric acid; In acetone; at 20 ℃; for 0.333333h;

DOI:10.1021/jm020018f

Reference yield:

3,5-bis-benzyloxy-4-[(2-benzyloxy-phenyl)-hydroxy-methyl]-benzoic acid tert-butyl ester (1027522-99-1) → 3,5-Bis-benzyloxy-4-(2-benzyloxy-benzoyl)-benzoic acid (167832-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CrO₃; aq. H₂SO₄ / acetone / 0.33 h / 20 °C

2: formic acid / 3 h / 20 °C

With chromium(VI) oxide; formic acid; sulfuric acid; In acetone; 1: Jones oxidation;

DOI:10.1021/jm020018f

upstream raw materials:

3,5-dibenzyloxy-4-bromobenzoic acid tert-butyl ester

2-(phenylmethoxy)benzaldehyde

Downstream raw materials:

3,5-Bis-benzyloxy-4-(2-benzyloxy-benzoyl)-benzoic acid