(Z)-7-((1R,2S,3R,5S)-3-(benzyloxy)-5-hydroxy-2-(((triisopropylsilyl)oxy)methyl)cyclopentyl)-5-heptenoic acid

Base Information

Chemical Name:(Z)-7-((1R,2S,3R,5S)-3-(benzyloxy)-5-hydroxy-2-(((triisopropylsilyl)oxy)methyl)cyclopentyl)-5-heptenoic acid
CAS No.:1236109-31-1
Molecular Formula:C₂₉H₄₈O₅Si
Molecular Weight:504.783
Hs Code.:

Synonyms:(Z)-7-((1R,2S,3R,5S)-3-(benzyloxy)-5-hydroxy-2-(((triisopropylsilyl)oxy)methyl)cyclopentyl)-5-heptenoic acid

Suppliers and Price of (Z)-7-((1R,2S,3R,5S)-3-(benzyloxy)-5-hydroxy-2-(((triisopropylsilyl)oxy)methyl)cyclopentyl)-5-heptenoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (Z)-7-((1R,2S,3R,5S)-3-(benzyloxy)-5-hydroxy-2-(((triisopropylsilyl)oxy)methyl)cyclopentyl)-5-heptenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (Z)-7-((1R,2S,3R,5S)-3-(benzyloxy)-5-hydroxy-2-(((triisopropylsilyl)oxy)methyl)cyclopentyl)-5-heptenoic acid

There total 3 articles about (Z)-7-((1R,2S,3R,5S)-3-(benzyloxy)-5-hydroxy-2-(((triisopropylsilyl)oxy)methyl)cyclopentyl)-5-heptenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1236109-30-0
(2S*/R*,3aR,4S,5R,6aS)-5-benzyloxy-4-[(triisopropylsilyloxy)methyl]hexahydro-2H-cyclopenta[b]furan-2-ol

: 17814-85-6
(4-carboxybutyl)triphenylphosphonium bromide

: 1236109-31-1
(Z)-7-((1R,2S,3R,5S)-3-(benzyloxy)-5-hydroxy-2-(((triisopropylsilyl)oxy)methyl)cyclopentyl)-5-heptenoic acid

Guidance literature:: (4-carboxybutyl)triphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃;

(2S*/R*,3aR,4S,5R,6aS)-5-benzyloxy-4-[(triisopropylsilyloxy)methyl]hexahydro-2H-cyclopenta[b]furan-2-ol; In tetrahydrofuran; at 20 ℃; Product distribution / selectivity;

Reference yield:

: 1236109-25-3
(3aR,4S,5R,6aS)-5-(benzyloxy)-4-(((triisopropylsilyl)oxy)methyl)hexahydro-2H-cyclopenta[b]furan-2-one

: 1236109-31-1
(Z)-7-((1R,2S,3R,5S)-3-(benzyloxy)-5-hydroxy-2-(((triisopropylsilyl)oxy)methyl)cyclopentyl)-5-heptenoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / toluene / 2 h / -22 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / Cooling with ice; Inert atmosphere

2.2: 3.17 h / Cooling with ice

With potassium tert-butylate; diisobutylaluminium hydride; In tetrahydrofuran; toluene;

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 1236109-31-1
(Z)-7-((1R,2S,3R,5S)-3-(benzyloxy)-5-hydroxy-2-(((triisopropylsilyl)oxy)methyl)cyclopentyl)-5-heptenoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide; toluene / 6 h / 20 - 40 °C

1.2: 5 h / 130 °C

2.1: diisobutylaluminium hydride / toluene / 2 h / -22 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 1 h / Cooling with ice; Inert atmosphere

3.2: 3.17 h / Cooling with ice

With 1H-imidazole; potassium tert-butylate; diisobutylaluminium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;