(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-butyric acid ethyl ester

Base Information

• Chemical Name: (2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-butyric acid ethyl ester
• CAS No.: 697751-89-6
• Molecular Formula: C₂₃H₃₂O₃Si
• Molecular Weight: 384.591
• Mol file: 697751-89-6.mol

Synonyms:(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-butyric acid ethyl ester

Chemical Property of (2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-butyric acid ethyl ester

There total 2 articles about (2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl anti-(2R,3R)-2-methyl-3-hydroxybutanoate (27372-03-8,51898-35-2,51898-36-3,63647-69-8,78088-27-4,78088-28-5,86853-34-1,92282-67-2,86853-33-0) + tert-butylchlorodiphenylsilane (58479-61-1) → (2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-butyric acid ethyl ester (697751-89-6)

Guidance literature:

With 1H-imidazole; In tetrahydrofuran;

DOI:10.1039/b401076k

Reference yield:

Ethyl (R)-3-hydroxybutanoate (24915-95-5) → (2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-butyric acid ethyl ester (697751-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / LDA / tetrahydrofuran / -78 °C

2: 96 percent / imidazole / tetrahydrofuran

With 1H-imidazole; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1039/b401076k

Reference yield: 94.0%

(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-butyric acid ethyl ester (697751-89-6) → (2R,3R)-3-(tert-butyldiphenylsilyloxy)-2-methylbutanal (697751-93-2)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; at -78 ℃;

DOI:10.1039/b401076k

upstream raw materials:

ethyl anti-(2R,3R)-2-methyl-3-hydroxybutanoate

tert-butylchlorodiphenylsilane

Ethyl (R)-3-hydroxybutanoate

Downstream raw materials:

(2R,3R)-3-(tert-butyldiphenylsilyloxy)-2-methylbutanal

(E)-(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-2-en-1-ol

(E)-(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-2-enoic acid methyl ester

2,2,2-Trichloro-acetimidic acid (E)-(4S,5R)-5-(tert-butyl-diphenyl-silanyloxy)-4-methyl-hex-2-enyl ester