2-((6S)-4-ethyl-2-oxo-6-phenylmorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

Base Information

Chemical Name:2-((6S)-4-ethyl-2-oxo-6-phenylmorpholin-3-yl)-N-(4-isopropylphenyl)acetamide
CAS No.:1312607-01-4
Molecular Formula:C₂₃H₂₈N₂O₃
Molecular Weight:380.487
Hs Code.:

Synonyms:2-((6S)-4-ethyl-2-oxo-6-phenylmorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

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Chemical Property of 2-((6S)-4-ethyl-2-oxo-6-phenylmorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

Chemical Property:

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Technology Process of 2-((6S)-4-ethyl-2-oxo-6-phenylmorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

There total 3 articles about 2-((6S)-4-ethyl-2-oxo-6-phenylmorpholin-3-yl)-N-(4-isopropylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99-88-7
4-Isopropylaniline

: C₁₄H₁₇NO₄

: 1312607-01-4
2-((6S)-4-ethyl-2-oxo-6-phenylmorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

Guidance literature:: C₁₄H₁₇NO₄; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

4-Isopropylaniline; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1312608-06-2
methyl 2-((6S)-4-ethyl-2-oxo-6-phenylmorpholin-3-yl)acetate

: 1312607-01-4
2-((6S)-4-ethyl-2-oxo-6-phenylmorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / 1,4-dioxane / 0.75 h / 20 °C

1.2: pH 5 - 7

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 0 - 20 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 56613-81-1,1936-63-6
(S)-2-Amino-1-phenyl-1-ethanol

: 1312607-01-4
2-((6S)-4-ethyl-2-oxo-6-phenylmorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 1 h / 0 °C

1.2: 3 h / 0 °C

2.1: toluene / 2 h / 10 °C / Reflux

3.1: lithium hexamethyldisilazane / tetrahydrofuran; ethylbenzene / 1.5 h / -70 °C

3.2: 2.5 h / -70 °C

4.1: water; lithium hydroxide / 1,4-dioxane / 0.75 h / 20 °C

4.2: pH 5 - 7

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 0 °C

5.2: 0 - 20 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; ethanol; ethylbenzene; N,N-dimethyl-formamide; toluene;