(+/-)-9-[(1-(4-monomethoxytrityl)aminomethyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Base Information

• Chemical Name: (+/-)-9-[(1-(4-monomethoxytrityl)aminomethyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine
• CAS No.: 889885-55-6
• Molecular Formula: C₆₂H₆₉N₆O₁₀P
• Molecular Weight: 1089.24

Synonyms:(+/-)-9-[(1-(4-monomethoxytrityl)aminomethyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Chemical Property of (+/-)-9-[(1-(4-monomethoxytrityl)aminomethyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-9-[(1-(4-monomethoxytrityl)aminomethyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

There total 11 articles about (+/-)-9-[(1-(4-monomethoxytrityl)aminomethyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(+/-)-9-[(1-(4-monomethoxytrityl)aminomethyl)(3-phosphonomethoxy)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-48-7) + Chloromethyl pivalate (18997-19-8) → (+/-)-9-[(1-(4-monomethoxytrityl)aminomethyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-55-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1080/15257770500268673

Reference yield:

(+/-)-9-[(1-hydroxymethyl)(3-tert-butylcarbonyloxy)propyl]adenine (889885-16-9) → (+/-)-9-[(1-(4-monomethoxytrityl)aminomethyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-55-6)

Guidance literature:

Multi-step reaction with 10 steps

1: 98 percent / pyridine / 20 h / 70 °C

2: 92 percent / NaOH / methanol; tetrahydrofuran / 16 h / 20 °C

3: 33 percent / NaH / dimethylformamide / 24 h / 20 °C

4: 55 percent / HCl / acetonitrile / 1 h / 20 °C

5: pyridine / 20 h / 20 °C

6: NaN₃ / dimethylformamide / 4 h / 100 °C

7: 0.687 g / Ph₃P; H₂O / tetrahydrofuran / 15 h / 20 °C

8: 69 percent / pyridine / 20 h / 70 °C

9: 52 percent / Et₃N; trimethylsilyliodide / dimethylformamide / 14 h / 20 °C

10: 48 percent / Et₃N / dimethylformamide / 72 h / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; sodium azide; trimethylsilyl iodide; water; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1080/15257770500268673

Reference yield:

(+/-)-9-[(1-tert-butyldimethylsilyloxymethyl)(3-pivaloyloxy)propyl]adenine (889885-15-8) → (+/-)-9-[(1-(4-monomethoxytrityl)aminomethyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-55-6)

Guidance literature:

Multi-step reaction with 11 steps

1: 21.1 g / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

2: 98 percent / pyridine / 20 h / 70 °C

3: 92 percent / NaOH / methanol; tetrahydrofuran / 16 h / 20 °C

4: 33 percent / NaH / dimethylformamide / 24 h / 20 °C

5: 55 percent / HCl / acetonitrile / 1 h / 20 °C

6: pyridine / 20 h / 20 °C

7: NaN₃ / dimethylformamide / 4 h / 100 °C

8: 0.687 g / Ph₃P; H₂O / tetrahydrofuran / 15 h / 20 °C

9: 69 percent / pyridine / 20 h / 70 °C

10: 52 percent / Et₃N; trimethylsilyliodide / dimethylformamide / 14 h / 20 °C

11: 48 percent / Et₃N / dimethylformamide / 72 h / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; sodium azide; trimethylsilyl iodide; tetrabutyl ammonium fluoride; water; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1080/15257770500268673

upstream raw materials:

(+/-)-9-[(1-(4-monomethoxytrityl)aminomethyl)(3-phosphonomethoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Chloromethyl pivalate

(+/-)-9-[(1-hydroxymethyl)(3-tert-butylcarbonyloxy)propyl]adenine

(+/-)-9-[(1-tert-butyldimethylsilyloxymethyl)(3-pivaloyloxy)propyl]adenine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 889885-55-6 (+/-)-9-[(1-(4-monomethoxytrityl)aminomethyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Send

Send

Metric Ton KG G Pound L ML

Send

Send