4-methylthio-1-(5-phenyl-(2H,3H-pyrazolo[5,1-b]1,3-oxazolidin-6-yl))benzene

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Chemical Name:4-methylthio-1-(5-phenyl-(2H,3H-pyrazolo[5,1-b]1,3-oxazolidin-6-yl))benzene
CAS No.:691881-11-5
Molecular Formula:C₁₈H₁₆N₂OS
Molecular Weight:308.404
Hs Code.:

Synonyms:4-methylthio-1-(5-phenyl-(2H,3H-pyrazolo[5,1-b]1,3-oxazolidin-6-yl))benzene

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Chemical Property of 4-methylthio-1-(5-phenyl-(2H,3H-pyrazolo[5,1-b]1,3-oxazolidin-6-yl))benzene

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Technology Process of 4-methylthio-1-(5-phenyl-(2H,3H-pyrazolo[5,1-b]1,3-oxazolidin-6-yl))benzene

There total 4 articles about 4-methylthio-1-(5-phenyl-(2H,3H-pyrazolo[5,1-b]1,3-oxazolidin-6-yl))benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 691881-10-4
1-(2-bromoethyl)-4-(4-methylthiophenyl)-3-phenylpyrazol-5-ol

: 691881-11-5
4-methylthio-1-(5-phenyl-(2H,3H-pyrazolo[5,1-b]1,3-oxazolidin-6-yl))benzene

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2004.01.012

Reference yield:

: 70290-37-8
(4-methylsulfanyl-phenyl)-acetic acid methyl ester

: 691881-11-5
4-methylthio-1-(5-phenyl-(2H,3H-pyrazolo[5,1-b]1,3-oxazolidin-6-yl))benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

1.2: 87 percent / tetrahydrofuran / 17 h / -78 - 20 °C

2.1: 62 percent / glacial AcOH / 1 h / 100 °C

3.1: 78 percent / carbon tetrabromide; polymer supported triphenylphosphine / dimethylformamide / 96 h / 20 °C

4.1: 54 percent / K₂CO₃ / dimethylformamide / 1 h / 20 °C

With polymer supported triphenylphosphine; carbon tetrabromide; potassium carbonate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.01.012

Reference yield:

: 691881-08-0
methyl 2-(4-methylthiophenyl)-3-oxo-3-phenylpropanoate

: 691881-11-5
4-methylthio-1-(5-phenyl-(2H,3H-pyrazolo[5,1-b]1,3-oxazolidin-6-yl))benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / glacial AcOH / 1 h / 100 °C

2: 78 percent / carbon tetrabromide; polymer supported triphenylphosphine / dimethylformamide / 96 h / 20 °C

3: 54 percent / K₂CO₃ / dimethylformamide / 1 h / 20 °C

With polymer supported triphenylphosphine; carbon tetrabromide; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.01.012