5'-O-(4,4'-dimethoxytrityl)-4-N-(6-nitroveratryloxycarbonyl)-2'-deoxycytidine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-4-N-(6-nitroveratryloxycarbonyl)-2'-deoxycytidine
CAS No.:243657-03-6
Molecular Formula:C₄₀H₄₀N₄O₁₂
Molecular Weight:768.777
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-4-N-(6-nitroveratryloxycarbonyl)-2'-deoxycytidine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-4-N-(6-nitroveratryloxycarbonyl)-2'-deoxycytidine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-4-N-(6-nitroveratryloxycarbonyl)-2'-deoxycytidine

There total 3 articles about 5'-O-(4,4'-dimethoxytrityl)-4-N-(6-nitroveratryloxycarbonyl)-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3992-42-5
2'-deoxycytidine monohydrochloride

: 243657-03-6
5'-O-(4,4'-dimethoxytrityl)-4-N-(6-nitroveratryloxycarbonyl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine

2: pyridine / 20 °C

3: 237 mg / water / methanol / 0.5 h

4: 40 percent / pyridine / 20 °C

With pyridine; water; In methanol; 1: Etherification / 2: Acylation / 3: Hydrolysis / 4: Etherification;
DOI:10.1021/jo990479h

Reference yield:

: 51432-42-9
4-Amino-1-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one

: 243657-03-6
5'-O-(4,4'-dimethoxytrityl)-4-N-(6-nitroveratryloxycarbonyl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 20 °C

2: 237 mg / water / methanol / 0.5 h

3: 40 percent / pyridine / 20 °C

With pyridine; water; In methanol; 1: Acylation / 2: Hydrolysis / 3: Etherification;
DOI:10.1021/jo990479h

Reference yield:

: [2-Oxo-1-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-1,2-dihydro-pyrimidin-4-yl]-carbamic acid 4,5-dimethoxy-2-nitro-benzyl ester

: 243657-03-6
5'-O-(4,4'-dimethoxytrityl)-4-N-(6-nitroveratryloxycarbonyl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 237 mg / water / methanol / 0.5 h

2: 40 percent / pyridine / 20 °C

With pyridine; water; In methanol; 1: Hydrolysis / 2: Etherification;
DOI:10.1021/jo990479h