(S)-2-Methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propane-1,3-dione

Base Information

• Chemical Name: (S)-2-Methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propane-1,3-dione
• CAS No.: 131700-99-7
• Molecular Formula: C₁₈H₁₇NO₄S
• Molecular Weight: 343.403

Synonyms:(S)-2-Methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propane-1,3-dione

Chemical Property of (S)-2-Methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propane-1,3-dione

Chemical Property:

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Technology Process of (S)-2-Methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propane-1,3-dione

There total 5 articles about (S)-2-Methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(S)-2-Methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-3-phenyl-propane-1,3-dione (131700-99-7) → (R)-2-Methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-3-phenyl-propane-1,3-dione (131700-99-7)

Guidance literature:

With triethylamine; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1016/S0040-4039(00)97794-3

Reference yield:

(R)-3-methyl-2,3-dihydrobenzo[d]isothiazoline 1,1-dioxide (130973-53-4) → (R)-2-Methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-3-phenyl-propane-1,3-dione (131700-99-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / NEt₃ / CH₂Cl₂ / 3 h / 0 °C

2: 1.) sodium hexamethyldisilazide / 1.) THF, -78 deg C, 0.5 h, 2.) -78 deg C, 0.5 to 1.0 h

3: 50 percent / NEt₃ / CH₂Cl₂ / 12 h / Ambient temperature

With sodium hexamethyldisilazane; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)97794-3

Reference yield:

(R)-3-methyl-2,3-dihydrobenzo[d]isothiazoline 1,1-dioxide (130973-53-4) → (S)-2-Methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-3-phenyl-propane-1,3-dione (131700-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NEt₃ / CH₂Cl₂ / 3 h / 0 °C

2: 1.) sodium hexamethyldisilazide / 1.) THF, -78 deg C, 0.5 h, 2.) -78 deg C, 0.5 to 1.0 h

With sodium hexamethyldisilazane; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)97794-3

upstream raw materials:

(R)-3-methyl-2,3-dihydrobenzo[d]isothiazoline 1,1-dioxide

1-((R)-3-Methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-propan-1-one

benzoyl chloride

Downstream raw materials:

(2S,3S)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one

(2S,3R)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one

(S)-2-(Benzhydrylidene-amino)-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one

2-(Benzhydrylidene-amino)-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-ethanone

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