1-(4-fluorophenyl)-3-(R)-[(4-fluorobenzoyl)methylthio]-4-(R)-{4-[N-(α-(R)-{N-[2-(t-butoxy)-(1S)-(t-butoxycarbonyl)ethyl]carbamoyl}benzyl)carbamoylmethoxy]phenyl}azetidin-2-one

Base Information

Chemical Name:1-(4-fluorophenyl)-3-(R)-[(4-fluorobenzoyl)methylthio]-4-(R)-{4-[N-(α-(R)-{N-[2-(t-butoxy)-(1S)-(t-butoxycarbonyl)ethyl]carbamoyl}benzyl)carbamoylmethoxy]phenyl}azetidin-2-one
CAS No.:858104-52-6
Molecular Formula:C₄₄H₄₇F₂N₃O₈S
Molecular Weight:815.935
Hs Code.:

1-(4-fluorophenyl)-3-(R)-[(4-fluorobenzoyl)methylthio]-4-(R)-{4-[N-(α-(R)-{N-[2-(t-butoxy)-(1S)-(t-butoxycarbonyl)ethyl]carbamoyl}benzyl)carbamoylmethoxy]phenyl}azetidin-2-one

Synonyms:1-(4-fluorophenyl)-3-(R)-[(4-fluorobenzoyl)methylthio]-4-(R)-{4-[N-(α-(R)-{N-[2-(t-butoxy)-(1S)-(t-butoxycarbonyl)ethyl]carbamoyl}benzyl)carbamoylmethoxy]phenyl}azetidin-2-one

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Chemical Property of 1-(4-fluorophenyl)-3-(R)-[(4-fluorobenzoyl)methylthio]-4-(R)-{4-[N-(α-(R)-{N-[2-(t-butoxy)-(1S)-(t-butoxycarbonyl)ethyl]carbamoyl}benzyl)carbamoylmethoxy]phenyl}azetidin-2-one

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(4-fluorophenyl)-3-(R)-[(4-fluorobenzoyl)methylthio]-4-(R)-{4-[N-(α-(R)-{N-[2-(t-butoxy)-(1S)-(t-butoxycarbonyl)ethyl]carbamoyl}benzyl)carbamoylmethoxy]phenyl}azetidin-2-one

There total 7 articles about 1-(4-fluorophenyl)-3-(R)-[(4-fluorobenzoyl)methylthio]-4-(R)-{4-[N-(α-(R)-{N-[2-(t-butoxy)-(1S)-(t-butoxycarbonyl)ethyl]carbamoyl}benzyl)carbamoylmethoxy]phenyl}azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 858103-97-6
N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}glycyl-L-asparagine

: 858104-50-4
(4-{(2R,3R)-1-(4-fluoro-phenyl)-3-[(RS)-2-(4-fluoro-phenyl)-2-oxoethylsulfanyl]-4-oxo-azetidin-2-yl}-phenoxy)-acetic acid

: 858104-52-6
1-(4-fluorophenyl)-3-(R)-[(4-fluorobenzoyl)methylthio]-4-(R)-{4-[N-(α-(R)-{N-[2-(t-butoxy)-(1S)-(t-butoxycarbonyl)ethyl]carbamoyl}benzyl)carbamoylmethoxy]phenyl}azetidin-2-one

Guidance literature:: N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}glycyl-L-asparagine; (4-{(2R,3R)-1-(4-fluoro-phenyl)-3-[(RS)-2-(4-fluoro-phenyl)-2-oxoethylsulfanyl]-4-oxo-azetidin-2-yl}-phenoxy)-acetic acid; With 4-methyl-morpholine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.166667h;

With (1,1,1-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; In DMF (N,N-dimethyl-formamide); for 22h;

Reference yield:

: 858104-48-0
(3R,4R)-1-(4-fluorophenyl)-3-[(3-nitropyridin-2-yl)dithio]-4-[4-(t-butoxycarbonylmethoxy)phenyl]azetidin-2-one

: 858104-52-6
1-(4-fluorophenyl)-3-(R)-[(4-fluorobenzoyl)methylthio]-4-(R)-{4-[N-(α-(R)-{N-[2-(t-butoxy)-(1S)-(t-butoxycarbonyl)ethyl]carbamoyl}benzyl)carbamoylmethoxy]phenyl}azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tributylphosphine; water / acetone / 0.5 h / 20 °C

1.2: 1.5 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3.1: 4-methyl-morpholine / DMF (N,N-dimethyl-formamide) / 0.17 h / 20 °C

3.2: 22 h

With 4-methyl-morpholine; tributylphosphine; water; trifluoroacetic acid; In DMF (N,N-dimethyl-formamide); dichloromethane; acetone;

Reference yield:

: 858104-44-6
tert-butyl (4-{[(4-fluorophenyl)imino]methyl}phenoxy)acetate

: 858104-52-6
1-(4-fluorophenyl)-3-(R)-[(4-fluorobenzoyl)methylthio]-4-(R)-{4-[N-(α-(R)-{N-[2-(t-butoxy)-(1S)-(t-butoxycarbonyl)ethyl]carbamoyl}benzyl)carbamoylmethoxy]phenyl}azetidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 0.08 h / 0 °C

1.2: 0.33 h / -40 - 0 °C

2.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 1 h / 90 °C

2.2: 18 h / 45 °C

2.3: 6 h / 45 °C

3.1: dichloromethane / 2 h / 0 °C

4.1: tributylphosphine; water / acetone / 0.5 h / 20 °C

4.2: 1.5 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

6.1: 4-methyl-morpholine / DMF (N,N-dimethyl-formamide) / 0.17 h / 20 °C

6.2: 22 h

With 4-methyl-morpholine; titanium(IV) isopropylate; tributylphosphine; water; titanium tetrachloride; N,O-bis-(trimethylsilyl)-acetamide; trifluoroacetic acid; In DMF (N,N-dimethyl-formamide); dichloromethane; acetone; toluene;