(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid tert-butyl ester

Base Information

Chemical Name:(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid tert-butyl ester
CAS No.:145337-56-0
Molecular Formula:C₁₉H₃₆N₂O₄
Molecular Weight:356.506
Hs Code.:

Synonyms:(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid tert-butyl ester

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Chemical Property of (R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid tert-butyl ester

Chemical Property:

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Technology Process of (R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid tert-butyl ester

There total 1 articles about (R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 145337-56-0
(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NEt₃ / ethyl acetate / Heating

2: pyridine

3: NaH

4: H₂ / Pd-C

5: N-methylmorpholine / toluene / Heating

6: EDAC, HOBT

With 4-methyl-morpholine; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In pyridine; ethyl acetate; toluene;
DOI:10.1016/S0960-894X(97)00416-2

Reference yield:

: 145337-56-0
(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid tert-butyl ester

: 145337-54-8
(R)-N⁴-Benzyloxy-N¹-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-2-isobutyl-succinamide

Guidance literature:: Multi-step reaction with 2 steps

1: CF₃SO₂OSiMe₃, NEt₃ / dioxane / Heating

2: EDAC, HOBT

With trimethylsilyl trifluoromethanesulfonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane;
DOI:10.1016/S0960-894X(97)00416-2

Reference yield:

: 145337-56-0
(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid tert-butyl ester

: 145337-55-9
(2R)-N₁-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N₄-hydroxy-2-(2-methylpropyl)-butanediamide

Guidance literature:: Multi-step reaction with 3 steps

1: CF₃SO₂OSiMe₃, NEt₃ / dioxane / Heating

2: EDAC, HOBT

3: H₂ / Pd-C / ethanol

With trimethylsilyl trifluoromethanesulfonate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol;
DOI:10.1016/S0960-894X(97)00416-2