2-{2-fluoro-4-[1(R)-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethyl]-phenyl}-propan-2-ol

Base Information

Chemical Name:2-{2-fluoro-4-[1(R)-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethyl]-phenyl}-propan-2-ol
CAS No.:1312017-30-3
Molecular Formula:C₂₃H₂₆F₂N₂O₂
Molecular Weight:400.468
Hs Code.:

Synonyms:2-{2-fluoro-4-[1(R)-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethyl]-phenyl}-propan-2-ol

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Chemical Property of 2-{2-fluoro-4-[1(R)-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethyl]-phenyl}-propan-2-ol

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Technology Process of 2-{2-fluoro-4-[1(R)-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethyl]-phenyl}-propan-2-ol

There total 6 articles about 2-{2-fluoro-4-[1(R)-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethyl]-phenyl}-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312017-29-0
2-{2-fluoro-4-[1-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethyl]-phenyl}-propan-2-ol

: 1312017-30-3
2-{2-fluoro-4-[1(R)-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethyl]-phenyl}-propan-2-ol

: 1312021-22-9
2-{2-fluoro-4-[1(S)-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethyl]-phenyl}-propan-2-ol

Guidance literature:: With Daicel IA-H; In hexanes; isopropyl alcohol; at 25 ℃; Resolution of racemate;

Reference yield:

: 603122-52-7
methyl 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1312017-30-3
2-{2-fluoro-4-[1(R)-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethyl]-phenyl}-propan-2-ol

: 1312021-22-9
2-{2-fluoro-4-[1(S)-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethyl]-phenyl}-propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Microwave irradiation

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 25 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 50 °C / 2585.81 Torr

4: tetrahydrofuran / 3 h / 0 °C

5: Daicel IA-H / isopropyl alcohol; hexanes / 25 °C / Resolution of racemate

With tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; hexanes; water; isopropyl alcohol;

Reference yield:

: 179232-29-2
methyl 4-bromo-2-fluorobenzoate

: 1312017-30-3
2-{2-fluoro-4-[1(R)-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethyl]-phenyl}-propan-2-ol

: 1312021-22-9
2-{2-fluoro-4-[1(S)-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethyl]-phenyl}-propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Microwave irradiation

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 25 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 50 °C / 2585.81 Torr

5: tetrahydrofuran / 3 h / 0 °C

6: Daicel IA-H / isopropyl alcohol; hexanes / 25 °C / Resolution of racemate

With tetrabutyl ammonium fluoride; hydrogen; potassium acetate; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; hexanes; water; dimethyl sulfoxide; isopropyl alcohol;