[1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol

Base Information

• Chemical Name: [1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol
• CAS No.: 10172-03-9
• Molecular Formula: C₃₇H₄₀N₂O₆
• Molecular Weight: 608.734
• Mol file: 10172-03-9.mol

Synonyms:Limacusine(7CI,8CI); Oxyacanthan-7-ol, 6,6',12'-trimethoxy-2,2'-dimethyl-, (1a)-;2H-1,24:12,15-Dietheno-6,10-metheno-16H-pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,oxyacanthan-7-ol deriv.; (+)-Limacusine; Limacusin

Chemical Property of [1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol

Chemical Property:

• Melting Point: 235-7°C
• PSA: 72.86000
• LogP: 6.73520

Purity/Quality:

98%,99%, ^*data from raw suppliers

LIMACUSINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: A second bisbenzylisoquinoline base from Limacia cuspidata (Miers.) Hook. f. et Thorn., the alkaloid is separated from the accompanying !imacine by chromato? graphy on a silica column. It crystallizes in colourless prisms from MeOH-Me2 CO and has [α]D + 110° (CHCI3). One hydroxyl group is present and the alkaloid yields the O-methyl ether as colourless needles, m.p. 210-2° C; [α]D + 90°, (CHCI3), shown to be identical with N-methyl-dihydroepistephanine B. The structure has been established by chemical interconversions with limacine and cuspidaline (q.v.).

Technology Process of [1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol

There total 1 articles about [1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

colorflammine (80550-39-6) → (+)-limacusine (10172-03-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; water; for 2h;

DOI:10.1021/jo00344a033

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + (+)-limacusine (10172-03-9) → (+)-O-methyl-limacusine (6013-35-0)

Guidance literature:

In methanol; diethyl ether; at 4 ℃; for 24h;

DOI:10.1016/0031-9422(88)83172-8

upstream raw materials:

colorflammine

Downstream raw materials:

(+)-O-methyl-limacusine

Refernces