Technology Process of 5-(4-octylphenyl)-1,3,4-thiadiazol-2-amine
There total 6 articles about 5-(4-octylphenyl)-1,3,4-thiadiazol-2-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / 3 h / Reflux; Cooling with ice
2.1: hydrazine hydrate / diethylene glycol / 2.5 h / Reflux
2.2: 4 h / Reflux
3.1: carbon disulfide / 50 °C
4.1: sodium hypobromide / tetrahydrofuran / 3 h / 0 - 5 °C / Reflux
5.1: trichlorophosphate / 4.5 h / 0 - 5 °C / Reflux
With
carbon disulfide; aluminum (III) chloride; sodium hypobromide; hydrazine hydrate; trichlorophosphate;
In
tetrahydrofuran; diethylene glycol;
1.1: Friedel Crafts acylation;
DOI:10.3184/174751911X13230201951890
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / 2 h / Reflux; Cooling with ice
2.1: aluminum (III) chloride / 3 h / Reflux; Cooling with ice
3.1: hydrazine hydrate / diethylene glycol / 2.5 h / Reflux
3.2: 4 h / Reflux
4.1: carbon disulfide / 50 °C
5.1: sodium hypobromide / tetrahydrofuran / 3 h / 0 - 5 °C / Reflux
6.1: trichlorophosphate / 4.5 h / 0 - 5 °C / Reflux
With
carbon disulfide; aluminum (III) chloride; thionyl chloride; sodium hypobromide; hydrazine hydrate; trichlorophosphate;
In
tetrahydrofuran; diethylene glycol;
2.1: Friedel Crafts acylation;
DOI:10.3184/174751911X13230201951890
