12-(ethanesulfonyl)-N-[4-(morpholin-4-yl)cyclohexyl]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraen-3-amine

Base Information

• Chemical Name: 12-(ethanesulfonyl)-N-[4-(morpholin-4-yl)cyclohexyl]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraen-3-amine
• CAS No.: 1447952-41-1
• Molecular Formula: C₂₁H₃₁N₅O₃S₂
• Molecular Weight: 465.641

Synonyms:12-(ethanesulfonyl)-N-[4-(morpholin-4-yl)cyclohexyl]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraen-3-amine

Chemical Property of 12-(ethanesulfonyl)-N-[4-(morpholin-4-yl)cyclohexyl]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraen-3-amine

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Technology Process of 12-(ethanesulfonyl)-N-[4-(morpholin-4-yl)cyclohexyl]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraen-3-amine

There total 9 articles about 12-(ethanesulfonyl)-N-[4-(morpholin-4-yl)cyclohexyl]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraen-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

→ 12-(ethanesulfonyl)-N-[4-(morpholin-4-yl)cyclohexyl]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1(9),2(7),3,5-tetraen-3-amine (1447952-41-1)

Guidance literature:

With triethylamine; In 1,2-dichloro-ethane; at 0 ℃; for 2h;

Reference yield:

C19H27N5OS (1447956-90-2) + Ethanesulfonyl chloride (594-44-5) → 12-(ethanesulfonyl)-N-[4-(morpholin-4-yl)cyclohexyl]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1(9),2(7),3,5-tetraen-3-amine (1447952-41-1)

Guidance literature:

With triethylamine; In 1,2-dichloro-ethane; at 0 ℃; for 2h;

Reference yield:

(1r,4r)-4-(morpholin-4-yl)cyclohexan-1-amine dihydrochloride (412356-24-2,1683576-26-2) → 12-(ethanesulfonyl)-N-[4-(morpholin-4-yl)cyclohexyl]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1(9),2(7),3,5-tetraen-3-amine (1447952-41-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; triethylamine / acetonitrile / 48 h / 80 °C

2: palladium 10% on activated carbon; hydrogen / 48 h / 40 °C

3: triethylamine / 1,2-dichloro-ethane / 2 h / 0 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In 1,2-dichloro-ethane; acetonitrile;

upstream raw materials:

(1r,4r)-4-(morpholin-4-yl)cyclohexan-1-amine dihydrochloride

C₁₉H₂₇N₅OS

Ethanesulfonyl chloride

C₂₇H₃₃N₅O₃S

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