2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-methyl-1H-pyrrol-3-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

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Chemical Name:2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-methyl-1H-pyrrol-3-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol
CAS No.:1443427-16-4
Molecular Formula:C₂₂H₁₆F₄N₆O
Molecular Weight:456.402
Hs Code.:

Synonyms:2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-methyl-1H-pyrrol-3-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

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Chemical Property of 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-methyl-1H-pyrrol-3-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

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Technology Process of 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-methyl-1H-pyrrol-3-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

There total 10 articles about 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-methyl-1H-pyrrol-3-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 288-94-8
1H-tetrazole

: 1443429-37-5
C₂₁H₁₄F₄N₂O

: 1443427-16-4
2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-methyl-1H-pyrrol-3-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 16h; Inert atmosphere;

Reference yield:

: 294182-28-8
5-bromo-2-((-2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridine

: 1443427-16-4
2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-methyl-1H-pyrrol-3-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

6.1: potassium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

6.2: 20 - 80 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 65 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1443429-26-2
2-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)-5-ethynylpyridine

: 1443427-16-4
2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-methyl-1H-pyrrol-3-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: potassium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

4.2: 20 - 80 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 65 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; N,N-dimethyl-formamide; acetonitrile;