2-(trimethylsilyl)ethyl 3-[1-(2-nitrophenyl)-5-oxo-3-(trimethylsilyl)-8-vinyl-5,6,7,8-tetrahydroindolizin-8-yl]propanoate

Base Information

• Chemical Name: 2-(trimethylsilyl)ethyl 3-[1-(2-nitrophenyl)-5-oxo-3-(trimethylsilyl)-8-vinyl-5,6,7,8-tetrahydroindolizin-8-yl]propanoate
• CAS No.: 1033282-32-4
• Molecular Formula: C₂₇H₃₈N₂O₅Si₂
• Molecular Weight: 526.78
• Mol file: 1033282-32-4.mol

Synonyms:2-(trimethylsilyl)ethyl 3-[1-(2-nitrophenyl)-5-oxo-3-(trimethylsilyl)-8-vinyl-5,6,7,8-tetrahydroindolizin-8-yl]propanoate

Chemical Property of 2-(trimethylsilyl)ethyl 3-[1-(2-nitrophenyl)-5-oxo-3-(trimethylsilyl)-8-vinyl-5,6,7,8-tetrahydroindolizin-8-yl]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(trimethylsilyl)ethyl 3-[1-(2-nitrophenyl)-5-oxo-3-(trimethylsilyl)-8-vinyl-5,6,7,8-tetrahydroindolizin-8-yl]propanoate

There total 1 articles about 2-(trimethylsilyl)ethyl 3-[1-(2-nitrophenyl)-5-oxo-3-(trimethylsilyl)-8-vinyl-5,6,7,8-tetrahydroindolizin-8-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-(trimethylsilyl)ethyl 4-ethylidene-7-[3-(2-nitrophenyl)-1H-pyrrol-1-yl]-7-oxopentanoate (1033282-31-3) → 2-(trimethylsilyl)ethyl 3-[1-(2-nitrophenyl)-5-oxo-3-(trimethylsilyl)-8-vinyl-5,6,7,8-tetrahydroindolizin-8-yl]propanoate (1033282-32-4)

Guidance literature:

With tert-Butyl peroxybenzoate; acetic acid; palladium(II) trifluoroacetate; In 1,4-dioxane; dimethyl sulfoxide; at 70 ℃; for 24h;

DOI:10.1002/anie.200705005

Reference yield: 100.0%

2-(trimethylsilyl)ethyl 3-[1-(2-nitrophenyl)-5-oxo-3-(trimethylsilyl)-8-vinyl-5,6,7,8-tetrahydroindolizin-8-yl]propanoate (1033282-32-4) → 2-(trimethylsilyl)ethyl 3-[1-(2-aminophenyl)-8-ethyl-5-oxo-3-(trimethylsilyl)-5,6,7,8-tetrahydroindolizin-8-yl]propanoate (1033282-33-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 1h;

DOI:10.1002/anie.200705005

upstream raw materials:

2-(trimethylsilyl)ethyl 4-ethylidene-7-[3-(2-nitrophenyl)-1H-pyrrol-1-yl]-7-oxopentanoate

Downstream raw materials:

2-(trimethylsilyl)ethyl 3-[1-(2-aminophenyl)-8-ethyl-5-oxo-3-(trimethylsilyl)-5,6,7,8-tetrahydroindolizin-8-yl]propanoate