5-(4-fluorophenyl)6-(4-((4-fluorophenyl)(2-(pyrrolidin-1-yl)ethoxy)methyl)piperidin-1-yl)pyrimidin-4-amine

Base Information

Chemical Name:5-(4-fluorophenyl)6-(4-((4-fluorophenyl)(2-(pyrrolidin-1-yl)ethoxy)methyl)piperidin-1-yl)pyrimidin-4-amine
CAS No.:1427595-84-3
Molecular Formula:C₂₈H₃₃F₂N₅O
Molecular Weight:493.6
Hs Code.:

Synonyms:5-(4-fluorophenyl)6-(4-((4-fluorophenyl)(2-(pyrrolidin-1-yl)ethoxy)methyl)piperidin-1-yl)pyrimidin-4-amine

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Chemical Property of 5-(4-fluorophenyl)6-(4-((4-fluorophenyl)(2-(pyrrolidin-1-yl)ethoxy)methyl)piperidin-1-yl)pyrimidin-4-amine

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Technology Process of 5-(4-fluorophenyl)6-(4-((4-fluorophenyl)(2-(pyrrolidin-1-yl)ethoxy)methyl)piperidin-1-yl)pyrimidin-4-amine

There total 5 articles about 5-(4-fluorophenyl)6-(4-((4-fluorophenyl)(2-(pyrrolidin-1-yl)ethoxy)methyl)piperidin-1-yl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(6-amino-5-(4-fluorophenyl)pyrimidin-4-yl)piperidin-4-yl-4-(chlorophenyl)methanol

: 7250-67-1
1-(2-chloroethyl)pyrrolidine hydrochloride

: 1427595-84-3
5-(4-fluorophenyl)6-(4-((4-fluorophenyl)(2-(pyrrolidin-1-yl)ethoxy)methyl)piperidin-1-yl)pyrimidin-4-amine

Guidance literature:: 1-(6-amino-5-(4-fluorophenyl)pyrimidin-4-yl)piperidin-4-yl-4-(chlorophenyl)methanol; With sodium hydride; In N,N-dimethyl-formamide; for 0.166667h;

1-(2-chloroethyl)pyrrolidine hydrochloride; In N,N-dimethyl-formamide; at 70 ℃;

Reference yield:

: 53220-41-0
4-(4-chlorobenzoyl)piperidine

: 1427595-84-3
5-(4-fluorophenyl)6-(4-((4-fluorophenyl)(2-(pyrrolidin-1-yl)ethoxy)methyl)piperidin-1-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate / 1,4-dioxane; water / 50 °C / Sealed tube

3.1: methanol; sodium tetrahydroborate

4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

4.2: 70 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; methanol; sodium tetrahydroborate; palladium diacetate; sodium hydride; potassium carbonate; caesium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1427595-75-2
[1-(6-amino-5-bromopyrimidin-4-yl)piperidin-4-yl]-(4-chlorophenyl)methanone

: 1427595-84-3
5-(4-fluorophenyl)6-(4-((4-fluorophenyl)(2-(pyrrolidin-1-yl)ethoxy)methyl)piperidin-1-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate / 1,4-dioxane; water / 50 °C / Sealed tube

2.1: methanol; sodium tetrahydroborate

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

3.2: 70 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; methanol; sodium tetrahydroborate; palladium diacetate; sodium hydride; caesium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;