6-Methyl-4'trifluoromethylbiphenyl-2-carboxylic acid (7-methoxycarbonylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-amide

Base Information

Chemical Name:6-Methyl-4'trifluoromethylbiphenyl-2-carboxylic acid (7-methoxycarbonylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-amide
CAS No.:256397-42-9
Molecular Formula:C₂₈H₂₇F₃N₂O₃
Molecular Weight:496.529
Hs Code.:

Synonyms:6-Methyl-4'trifluoromethylbiphenyl-2-carboxylic acid (7-methoxycarbonylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-amide

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Chemical Property of 6-Methyl-4'trifluoromethylbiphenyl-2-carboxylic acid (7-methoxycarbonylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-amide

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Technology Process of 6-Methyl-4'trifluoromethylbiphenyl-2-carboxylic acid (7-methoxycarbonylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-amide

There total 9 articles about 6-Methyl-4'trifluoromethylbiphenyl-2-carboxylic acid (7-methoxycarbonylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37949-03-4
5,6,8,9-tetrahydrobenzo[7]annulen-7-one

: 256397-42-9
6-Methyl-4'trifluoromethylbiphenyl-2-carboxylic acid (7-methoxycarbonylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 56 percent / NH₂OH*HCl; aq. Na₂CO₃

2: NaBH₄; TiCl₄ / dimethylformamide

3: iPr₂NEt / CH₂Cl₂ / 1 h

4: fuming HNO₃; CF₃COOH / 3 h / 0 °C

5: H₂ / 10percent Pd/C / ethyl acetate / 16 h / 20 °C / 2585.81 Torr

6: pyridine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; sodium tetrahydroborate; hydroxylamine hydrochloride; hydrogen; nitric acid; titanium tetrachloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 10percent Pd/C; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm010294e

Reference yield:

: 92367-49-2
hydroxylamine, N-(6,7,8,9-tetrahydro-5H-benzo[a]cyclohepten-7-yl)-

: 256397-42-9
6-Methyl-4'trifluoromethylbiphenyl-2-carboxylic acid (7-methoxycarbonylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄; TiCl₄ / dimethylformamide

2: iPr₂NEt / CH₂Cl₂ / 1 h

3: fuming HNO₃; CF₃COOH / 3 h / 0 °C

4: H₂ / 10percent Pd/C / ethyl acetate / 16 h / 20 °C / 2585.81 Torr

5: pyridine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; sodium tetrahydroborate; hydrogen; nitric acid; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 10percent Pd/C; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm010294e

Reference yield:

: 450-60-2
5H-benzo[a]cyclohepten-7-amine, 6,7,8,9-tetrahydro-

: 256397-42-9
6-Methyl-4'trifluoromethylbiphenyl-2-carboxylic acid (7-methoxycarbonylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: iPr₂NEt / CH₂Cl₂ / 1 h

2: fuming HNO₃; CF₃COOH / 3 h / 0 °C

3: H₂ / 10percent Pd/C / ethyl acetate / 16 h / 20 °C / 2585.81 Torr

4: pyridine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 10percent Pd/C; In dichloromethane; ethyl acetate;
DOI:10.1021/jm010294e