(R)-6,6-difluoro-5-[2-fluoro-5-(2-methyl-thiazol-4-ylethynyl)-phenyl]-5,7,7-trimethyl-[1,4]oxazepan-3-one

Base Information

Chemical Name:(R)-6,6-difluoro-5-[2-fluoro-5-(2-methyl-thiazol-4-ylethynyl)-phenyl]-5,7,7-trimethyl-[1,4]oxazepan-3-one
CAS No.:1401241-84-6
Molecular Formula:C₂₀H₁₉F₃N₂O₂S
Molecular Weight:408.444
Hs Code.:

Synonyms:(R)-6,6-difluoro-5-[2-fluoro-5-(2-methyl-thiazol-4-ylethynyl)-phenyl]-5,7,7-trimethyl-[1,4]oxazepan-3-one

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Chemical Property of (R)-6,6-difluoro-5-[2-fluoro-5-(2-methyl-thiazol-4-ylethynyl)-phenyl]-5,7,7-trimethyl-[1,4]oxazepan-3-one

Chemical Property:

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Technology Process of (R)-6,6-difluoro-5-[2-fluoro-5-(2-methyl-thiazol-4-ylethynyl)-phenyl]-5,7,7-trimethyl-[1,4]oxazepan-3-one

There total 10 articles about (R)-6,6-difluoro-5-[2-fluoro-5-(2-methyl-thiazol-4-ylethynyl)-phenyl]-5,7,7-trimethyl-[1,4]oxazepan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1401241-40-4
(R)-6,6-difluoro-5-(2-fluoro-5-iodo-phenyl)-5,7,7-trimethyl-[1,4]oxazepan-3-one

: 329203-85-2
2-methyl-4-[(trimethylsilyl)ethynyl]-1,3-thiazole

: 1401241-84-6
(R)-6,6-difluoro-5-[2-fluoro-5-(2-methyl-thiazol-4-ylethynyl)-phenyl]-5,7,7-trimethyl-[1,4]oxazepan-3-one

Guidance literature:: With copper(l) iodide; tetra-(n-butyl)ammonium iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 40 - 60 ℃; for 16h; Inert atmosphere;

Reference yield:

: (R)-N-((1E)-1-(5-bromo-2-fluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1401241-84-6
(R)-6,6-difluoro-5-[2-fluoro-5-(2-methyl-thiazol-4-ylethynyl)-phenyl]-5,7,7-trimethyl-[1,4]oxazepan-3-one

Guidance literature:: Multi-step reaction with 9 steps

1: zinc / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

2: tetrahydrofuran; 2-methyltetrahydrofuran / 18 h / -78 - 23 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 8 h / 23 - 70 °C / Inert atmosphere

4: sodium periodate / ruthenium trichloride / ethyl acetate; acetonitrile; water / 3 h / 23 °C

5: thionyl chloride / 18 h / 23 °C / Reflux

6: dichloromethane / 0.5 h / 0 - 23 °C

7: trimethylaluminum / toluene / 2 h / 23 °C

8: sodium iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / 1,4-dioxane / 110 °C

9: triethylamine; tetra-(n-butyl)ammonium iodide; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 40 - 60 °C / Inert atmosphere

With sodium periodate; copper(l) iodide; thionyl chloride; trimethylaluminum; tetra-(n-butyl)ammonium iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; triethylamine; sodium iodide; zinc; ruthenium trichloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; 1: Reformatsky Reaction;

Reference yield:

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 1401241-84-6
(R)-6,6-difluoro-5-[2-fluoro-5-(2-methyl-thiazol-4-ylethynyl)-phenyl]-5,7,7-trimethyl-[1,4]oxazepan-3-one

Guidance literature:: Multi-step reaction with 10 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / Reflux

2: zinc / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3: tetrahydrofuran; 2-methyltetrahydrofuran / 18 h / -78 - 23 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 8 h / 23 - 70 °C / Inert atmosphere

5: sodium periodate / ruthenium trichloride / ethyl acetate; acetonitrile; water / 3 h / 23 °C

6: thionyl chloride / 18 h / 23 °C / Reflux

7: dichloromethane / 0.5 h / 0 - 23 °C

8: trimethylaluminum / toluene / 2 h / 23 °C

9: sodium iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / 1,4-dioxane / 110 °C

10: triethylamine; tetra-(n-butyl)ammonium iodide; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 40 - 60 °C / Inert atmosphere

With titanium(IV) tetraethanolate; sodium periodate; copper(l) iodide; thionyl chloride; trimethylaluminum; tetra-(n-butyl)ammonium iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; triethylamine; sodium iodide; zinc; ruthenium trichloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; 2: Reformatsky Reaction;