5-(4-chlorophenyl)-2-{[5-(2-chlorophenyl)-2-thienyl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxy-propyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:5-(4-chlorophenyl)-2-{[5-(2-chlorophenyl)-2-thienyl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxy-propyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS No.:1332501-93-5
Molecular Formula:C₂₂H₁₆Cl₂F₃N₃O₂S
Molecular Weight:514.355
Hs Code.:

Synonyms:5-(4-chlorophenyl)-2-{[5-(2-chlorophenyl)-2-thienyl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxy-propyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

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Chemical Property of 5-(4-chlorophenyl)-2-{[5-(2-chlorophenyl)-2-thienyl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxy-propyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

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Technology Process of 5-(4-chlorophenyl)-2-{[5-(2-chlorophenyl)-2-thienyl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxy-propyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 10 articles about 5-(4-chlorophenyl)-2-{[5-(2-chlorophenyl)-2-thienyl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxy-propyl]-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

: 1245623-49-7
5-(4-chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

: 1332503-09-9
2-(bromomethyl)-5-(2-chlorophenyl)thiophene

: 1332501-93-5
5-(4-chlorophenyl)-2-{[5-(2-chlorophenyl)-2-thienyl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxy-propyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: With caesium carbonate; In acetonitrile; for 20h; Reflux;

Reference yield:

: 3900-89-8
2-Chlorobenzeneboronic acid

: 1332501-93-5
5-(4-chlorophenyl)-2-{[5-(2-chlorophenyl)-2-thienyl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxy-propyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 20 h / 110 °C / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 80 °C

3.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / 1 h / 0 °C

3.2: 1 h / 0 °C

4.1: triphenylphosphine; carbon tetrabromide / tetrahydrofuran / 16 h / 20 °C

5.1: caesium carbonate / acetonitrile / 20 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; water; sodium carbonate; caesium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;

Reference yield:

: 500604-91-1
5-(2-chlorophenyl)thiophene-2-carboxylic acid

: 1332501-93-5
5-(4-chlorophenyl)-2-{[5-(2-chlorophenyl)-2-thienyl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxy-propyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: triphenylphosphine; carbon tetrabromide / tetrahydrofuran / 16 h / 20 °C

3.1: caesium carbonate / acetonitrile / 20 h / Reflux

With carbon tetrabromide; caesium carbonate; triethylamine; triphenylphosphine; isobutyl chloroformate; In tetrahydrofuran; acetonitrile;