methyl 7-[1-(3-methoxy-4-benzyloxyphenyl)-2,3-dihydroxypropoxy]-2-(4-methoxyphenyl)-1,3-benzodioxole-5-carboxylate

Base Information

Chemical Name:methyl 7-[1-(3-methoxy-4-benzyloxyphenyl)-2,3-dihydroxypropoxy]-2-(4-methoxyphenyl)-1,3-benzodioxole-5-carboxylate
CAS No.:853057-19-9
Molecular Formula:C₃₃H₃₂O₁₀
Molecular Weight:588.611
Hs Code.:

Synonyms:methyl 7-[1-(3-methoxy-4-benzyloxyphenyl)-2,3-dihydroxypropoxy]-2-(4-methoxyphenyl)-1,3-benzodioxole-5-carboxylate

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Chemical Property of methyl 7-[1-(3-methoxy-4-benzyloxyphenyl)-2,3-dihydroxypropoxy]-2-(4-methoxyphenyl)-1,3-benzodioxole-5-carboxylate

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Technology Process of methyl 7-[1-(3-methoxy-4-benzyloxyphenyl)-2,3-dihydroxypropoxy]-2-(4-methoxyphenyl)-1,3-benzodioxole-5-carboxylate

There total 4 articles about methyl 7-[1-(3-methoxy-4-benzyloxyphenyl)-2,3-dihydroxypropoxy]-2-(4-methoxyphenyl)-1,3-benzodioxole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 853057-17-7
methyl 7-[1-(3-methoxy-4-benzyloxyphenyl)prop-2-enyloxy]-2-(4-methoxyphenyl)-1,3-benzodioxole-5-carboxylate

: 853057-19-9
methyl 7-[1-(3-methoxy-4-benzyloxyphenyl)-2,3-dihydroxypropoxy]-2-(4-methoxyphenyl)-1,3-benzodioxole-5-carboxylate

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine 4-oxide monohydrate; In water; tert-butyl alcohol; for 40h;
DOI:10.1016/j.tet.2005.02.024

Reference yield:

: 848772-90-7
methyl 7-hydroxy-2-(4-methoxyphenyl)benzo[d][1,3]dioxole-5-carboxylate

: 853057-19-9
methyl 7-[1-(3-methoxy-4-benzyloxyphenyl)-2,3-dihydroxypropoxy]-2-(4-methoxyphenyl)-1,3-benzodioxole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-bis(diphenylphosphino)propane; diethyl azodicarboxylate / dioxane / 16 h / 0 - 20 °C

2: 48 percent / OsO₄; 4-methylmorpholine N-oxide monohydrate / 2-methyl-propan-2-ol; H₂O / 40 h

With osmium(VIII) oxide; 1,2-bis(diphenylphosphino)propane; 4-methylmorpholine 4-oxide monohydrate; diethylazodicarboxylate; In 1,4-dioxane; water; tert-butyl alcohol; 1: Mitsunobu reaction;
DOI:10.1016/j.tet.2005.02.024

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 853057-19-9
methyl 7-[1-(3-methoxy-4-benzyloxyphenyl)-2,3-dihydroxypropoxy]-2-(4-methoxyphenyl)-1,3-benzodioxole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / p-toluene-sulfonic acid monohydrate / toluene / 2 h / Heating

2: 1,2-bis(diphenylphosphino)propane; diethyl azodicarboxylate / dioxane / 16 h / 0 - 20 °C

3: 48 percent / OsO₄; 4-methylmorpholine N-oxide monohydrate / 2-methyl-propan-2-ol; H₂O / 40 h

With osmium(VIII) oxide; toluene-4-sulfonic acid; 1,2-bis(diphenylphosphino)propane; 4-methylmorpholine 4-oxide monohydrate; diethylazodicarboxylate; In 1,4-dioxane; water; toluene; tert-butyl alcohol; 2: Mitsunobu reaction;
DOI:10.1016/j.tet.2005.02.024