(Z)-4-(4-(2-(4-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)but-1-yn-1-yl)phenyl)-1,2-diphenylvinyl)phenyl)but-3-yn-1-yl (2-cyanoethyl) diisopropylphosphoramidite

Base Information

• Chemical Name: (Z)-4-(4-(2-(4-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)but-1-yn-1-yl)phenyl)-1,2-diphenylvinyl)phenyl)but-3-yn-1-yl (2-cyanoethyl) diisopropylphosphoramidite
• CAS No.: 1443332-50-0
• Molecular Formula: C₆₄H₆₃N₂O₅P
• Molecular Weight: 971.188
• Mol file: 1443332-50-0.mol

Synonyms:(Z)-4-(4-(2-(4-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)but-1-yn-1-yl)phenyl)-1,2-diphenylvinyl)phenyl)but-3-yn-1-yl (2-cyanoethyl) diisopropylphosphoramidite

Chemical Property of (Z)-4-(4-(2-(4-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)but-1-yn-1-yl)phenyl)-1,2-diphenylvinyl)phenyl)but-3-yn-1-yl (2-cyanoethyl) diisopropylphosphoramidite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-4-(4-(2-(4-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)but-1-yn-1-yl)phenyl)-1,2-diphenylvinyl)phenyl)but-3-yn-1-yl (2-cyanoethyl) diisopropylphosphoramidite

There total 3 articles about (Z)-4-(4-(2-(4-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)but-1-yn-1-yl)phenyl)-1,2-diphenylvinyl)phenyl)but-3-yn-1-yl (2-cyanoethyl) diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(Z)-4-(4-(2-(4-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)but-1-yn-1-yl)phenyl)-1,2-diphenylvinyl)phenyl)but-3-yn-1-ol (1443332-38-4) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → (Z)-4-(4-(2-(4-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)but-1-yn-1-yl)phenyl)-1,2-diphenylvinyl)phenyl)but-3-yn-1-yl (2-cyanoethyl) diisopropylphosphoramidite (1443332-50-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c3cc42706d

Reference yield:

(4-bromophenyl)(phenyl)methanone (90-90-4) → (Z)-4-(4-(2-(4-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)but-1-yn-1-yl)phenyl)-1,2-diphenylvinyl)phenyl)but-3-yn-1-yl (2-cyanoethyl) diisopropylphosphoramidite (1443332-50-0)

Guidance literature:

Multi-step reaction with 4 steps

1: zinc; titanium tetrachloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 70 °C / Inert atmosphere

3: pyridine; dmap / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; titanium tetrachloride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c3cc42706d

Reference yield:

1,2-bis(4-bromophenyl)-1,2-diphenylethylene (184239-35-8) → (Z)-4-(4-(2-(4-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)but-1-yn-1-yl)phenyl)-1,2-diphenylvinyl)phenyl)but-3-yn-1-yl (2-cyanoethyl) diisopropylphosphoramidite (1443332-50-0)

Guidance literature:

Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 70 °C / Inert atmosphere

2: pyridine; dmap / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c3cc42706d

upstream raw materials:

1,2-bis(4-bromophenyl)-1,2-diphenylethylene

(Z)-4-(4-(2-(4-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)but-1-yn-1-yl)phenyl)-1,2-diphenylvinyl)phenyl)but-3-yn-1-ol

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

(4-bromophenyl)(phenyl)methanone