4-hydroxy-N’-[(E)-(4-chlorophenyl)methylidene]benzohydrazide

Base Information

• Chemical Name: 4-hydroxy-N’-[(E)-(4-chlorophenyl)methylidene]benzohydrazide
• CAS No.: 1415703-67-1
• Molecular Formula: C₁₄H₁₁ClN₂O₂
• Molecular Weight: 274.707
• Mol file: 1415703-67-1.mol

Synonyms:4-hydroxy-N’-[(E)-(4-chlorophenyl)methylidene]benzohydrazide

Chemical Property of 4-hydroxy-N’-[(E)-(4-chlorophenyl)methylidene]benzohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-N’-[(E)-(4-chlorophenyl)methylidene]benzohydrazide

There total 2 articles about 4-hydroxy-N’-[(E)-(4-chlorophenyl)methylidene]benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.4%

4-chlorobenzaldehyde (104-88-1) + 4-hydroxybenzoic acid hydrazide (5351-23-5) → 4-hydroxy-N’-[(E)-(4-chlorophenyl)methylidene]benzohydrazide (1415703-67-1)

Guidance literature:

With acetic acid; In ethanol; for 3h; Reflux;

DOI:10.1371/journal.pone.0227549

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 4-hydroxy-N’-[(E)-(4-chlorophenyl)methylidene]benzohydrazide (1415703-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate; acetic acid / ethanol / 24 h / Reflux

2: acetic acid / isopropyl alcohol / 24 h / 20 °C

With hydrazine hydrate; acetic acid; In ethanol; isopropyl alcohol;

DOI:10.2174/1573406415666190724142951

upstream raw materials:

4-chlorobenzaldehyde

4-hydroxybenzoic acid hydrazide

methyl 4-hydroxylbenzoate