(4-benzyl-11-methyl-10-oxo-2,3,4,7,8,9,10,11-octahydro-1-oxa-4,9,11-triaza-benzo[a]fluoren-2-yl)-acetic acid ethyl ester

Base Information

Chemical Name:(4-benzyl-11-methyl-10-oxo-2,3,4,7,8,9,10,11-octahydro-1-oxa-4,9,11-triaza-benzo[a]fluoren-2-yl)-acetic acid ethyl ester
CAS No.:497945-94-5
Molecular Formula:C₂₅H₂₇N₃O₄
Molecular Weight:433.507
Hs Code.:

(4-benzyl-11-methyl-10-oxo-2,3,4,7,8,9,10,11-octahydro-1-oxa-4,9,11-triaza-benzo[<i>a</i>]fluoren-2-yl)-acetic acid ethyl ester

Synonyms:(4-benzyl-11-methyl-10-oxo-2,3,4,7,8,9,10,11-octahydro-1-oxa-4,9,11-triaza-benzo[a]fluoren-2-yl)-acetic acid ethyl ester

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Chemical Property of (4-benzyl-11-methyl-10-oxo-2,3,4,7,8,9,10,11-octahydro-1-oxa-4,9,11-triaza-benzo[a]fluoren-2-yl)-acetic acid ethyl ester

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Technology Process of (4-benzyl-11-methyl-10-oxo-2,3,4,7,8,9,10,11-octahydro-1-oxa-4,9,11-triaza-benzo[a]fluoren-2-yl)-acetic acid ethyl ester

There total 5 articles about (4-benzyl-11-methyl-10-oxo-2,3,4,7,8,9,10,11-octahydro-1-oxa-4,9,11-triaza-benzo[a]fluoren-2-yl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 462117-35-7
ethyl 4-benzyl-2-[(ethoxycarbonyl)methyl]-9-methyl-2,3,4,9-tetrahydro[1,4]oxazino[3,2-g]indole-8-carboxylate

: 497945-94-5
(4-benzyl-11-methyl-10-oxo-2,3,4,7,8,9,10,11-octahydro-1-oxa-4,9,11-triaza-benzo[a]fluoren-2-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: AlCl₃ / CH₂Cl₂ / 0.05 h / 0 °C

1.2: 99 percent / CH₂Cl₂ / 1 h / 0 °C

2.1: 94 percent / NH₄OAc / 2 h / Heating

3.1: 79 percent / NaBH₄; silica gel / CHCl₃; propan-2-ol / 4 h / 20 °C

4.1: H₂ / Raney Ni / dimethylformamide / 28 h / 20 °C / 760 Torr

5.1: DBU / dimethylformamide / 9 h / 20 °C

With sodium tetrahydroborate; aluminium trichloride; ammonium acetate; hydrogen; silica gel; 1,8-diazabicyclo[5.4.0]undec-7-ene; nickel; In dichloromethane; chloroform; N,N-dimethyl-formamide; isopropyl alcohol; 1.2: Rieche reaction;

Reference yield:

: 3-(2-amino-ethyl)-6-benzyl-8-ethoxycarbonylmethyl-1-methyl-1,6,7,8-tetrahydro-9-oxa-1,6-diaza-cyclopenta[a]naphthalene-2-carboxylic acid ethyl ester

: 497945-94-5
(4-benzyl-11-methyl-10-oxo-2,3,4,7,8,9,10,11-octahydro-1-oxa-4,9,11-triaza-benzo[a]fluoren-2-yl)-acetic acid ethyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 9h;

Reference yield:

: 497945-84-3
6-benzyl-8-ethoxycarbonylmethyl-3-formyl-1-methyl-1,6,7,8-tetrahydro-9-oxa-1,6-diaza-cyclopenta[a]naphthalene-2-carboxylic acid ethyl ester

: 497945-94-5
(4-benzyl-11-methyl-10-oxo-2,3,4,7,8,9,10,11-octahydro-1-oxa-4,9,11-triaza-benzo[a]fluoren-2-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / NH₄OAc / 2 h / Heating

2: 79 percent / NaBH₄; silica gel / CHCl₃; propan-2-ol / 4 h / 20 °C

3: H₂ / Raney Ni / dimethylformamide / 28 h / 20 °C / 760 Torr

4: DBU / dimethylformamide / 9 h / 20 °C

With sodium tetrahydroborate; ammonium acetate; hydrogen; silica gel; 1,8-diazabicyclo[5.4.0]undec-7-ene; nickel; In chloroform; N,N-dimethyl-formamide; isopropyl alcohol;