methyl 3-(2,5-dioxo-1-phenyl-4-(pyridin-2-ylthio)pyrrolidin-3-yl)propanoate

Base Information

• Chemical Name: methyl 3-(2,5-dioxo-1-phenyl-4-(pyridin-2-ylthio)pyrrolidin-3-yl)propanoate
• CAS No.: 934683-37-1
• Molecular Formula: C₁₉H₁₈N₂O₄S
• Molecular Weight: 370.429
• Mol file: 934683-37-1.mol

Synonyms:methyl 3-(2,5-dioxo-1-phenyl-4-(pyridin-2-ylthio)pyrrolidin-3-yl)propanoate

Chemical Property of methyl 3-(2,5-dioxo-1-phenyl-4-(pyridin-2-ylthio)pyrrolidin-3-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(2,5-dioxo-1-phenyl-4-(pyridin-2-ylthio)pyrrolidin-3-yl)propanoate

There total 2 articles about methyl 3-(2,5-dioxo-1-phenyl-4-(pyridin-2-ylthio)pyrrolidin-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-2(1H)-pyridinethione (1121-30-8) → methyl 3-(2,5-dioxo-1-phenyl-4-(pyridin-2-ylthio)pyrrolidin-3-yl)propanoate (934683-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 2 h / 20 °C

2: CH₂Cl₂ / 0.5 h / 10 - 15 °C / Irradiation

With dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/j.ejmech.2006.09.014

Reference yield:

N-phenyl-maleimide (941-69-5) + N-(3'-Methoxycarbonylpropionyloxy)pyridine-2-thione (162970-04-9) → methyl 3-(2,5-dioxo-1-phenyl-4-(pyridin-2-ylthio)pyrrolidin-3-yl)propanoate (934683-37-1)

Guidance literature:

In dichloromethane; at 10 - 15 ℃; for 0.5h; Irradiation;

DOI:10.1016/j.ejmech.2006.09.014

Reference yield: 90.0%

methyl 3-(2,5-dioxo-1-phenyl-4-(pyridin-2-ylthio)pyrrolidin-3-yl)propanoate (934683-37-1) → methyl 3-(2,5-dioxo-1-phenyl-2,5-dihydro-1H-pyrrol-3-yl)propanoate (913954-29-7)

Guidance literature:

methyl 3-(2,5-dioxo-1-phenyl-4-(pyridin-2-ylthio)pyrrolidin-3-yl)propanoate; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 1h;

In toluene; at 110 ℃; for 1h; Further stages.;

DOI:10.1016/j.ejmech.2006.09.014

upstream raw materials:

N-phenyl-maleimide

N-(3'-Methoxycarbonylpropionyloxy)pyridine-2-thione

1-hydroxy-2(1H)-pyridinethione

Downstream raw materials:

methyl 3-(2,5-dioxo-1-phenyl-2,5-dihydro-1H-pyrrol-3-yl)propanoate