1-[3-C-ethynyl-5-O-[1-ethoxy-1-(4-nitrophenyl)methyl]-β-D-ribo-pentofuranosyl]cytosine

Base Information

• Chemical Name: 1-[3-C-ethynyl-5-O-[1-ethoxy-1-(4-nitrophenyl)methyl]-β-D-ribo-pentofuranosyl]cytosine
• CAS No.: 616239-67-9
• Molecular Formula: C₂₀H₂₂N₄O₈
• Molecular Weight: 446.417
• Mol file: 616239-67-9.mol

Synonyms:1-[3-C-ethynyl-5-O-[1-ethoxy-1-(4-nitrophenyl)methyl]-β-D-ribo-pentofuranosyl]cytosine

Chemical Property of 1-[3-C-ethynyl-5-O-[1-ethoxy-1-(4-nitrophenyl)methyl]-β-D-ribo-pentofuranosyl]cytosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3-C-ethynyl-5-O-[1-ethoxy-1-(4-nitrophenyl)methyl]-β-D-ribo-pentofuranosyl]cytosine

There total 1 articles about 1-[3-C-ethynyl-5-O-[1-ethoxy-1-(4-nitrophenyl)methyl]-β-D-ribo-pentofuranosyl]cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

p-nitrobenzaldehyde diethyl acetal (2403-62-5) + 3'-ethynylcytidine (180300-43-0) → 1-[3-C-ethynyl-5-O-[1-ethoxy-1-(4-nitrophenyl)methyl]-β-D-ribo-pentofuranosyl]cytosine (616239-67-9)

Guidance literature:

With sulfuric acid; In dimethyl sulfoxide; for 6h; reduced pressure;

DOI:10.1016/S0968-0896(03)00104-4

Reference yield: 8.9%

1-[3-C-ethynyl-5-O-[1-ethoxy-1-(4-nitrophenyl)methyl]-β-D-ribo-pentofuranosyl]cytosine (616239-67-9) → 1-[3-C-ethynyl-5-O-[1-ethoxy-1-(4-aminophenyl)methyl]-β-D-ribo-pentofuranosyl]cytosine

Guidance literature:

With sodium dithionite; di(C₈H₇)-viologen; potassium carbonate; In dichloromethane; water; at 20 ℃; for 2h;

DOI:10.1016/S0968-0896(03)00104-4

Reference yield:

1-[3-C-ethynyl-5-O-[1-ethoxy-1-(4-nitrophenyl)methyl]-β-D-ribo-pentofuranosyl]cytosine (616239-67-9) → 4-aminobenzaldehyde (556-18-3,28107-09-7)

Guidance literature:

With rat liver S-9; potassium chloride; magnesium chloride; NADPH; In water; at 37 ℃; for 3h; pH=7.4;

DOI:10.1016/S0968-0896(03)00104-4

upstream raw materials:

p-nitrobenzaldehyde diethyl acetal

3'-ethynylcytidine

Downstream raw materials:

4-aminobenzaldehyde