2-{(R)-3-[(2R,3R,4R)-2,3-Bis-benzyloxy-4-(tert-butoxycarbonyl-methyl-amino)-5-methoxy-pentanoylamino]-1-methyl-propyl}-oxazole-4-carboxylic acid methyl ester

Base Information

Chemical Name:2-{(R)-3-[(2R,3R,4R)-2,3-Bis-benzyloxy-4-(tert-butoxycarbonyl-methyl-amino)-5-methoxy-pentanoylamino]-1-methyl-propyl}-oxazole-4-carboxylic acid methyl ester
CAS No.:144681-93-6
Molecular Formula:C₃₅H₄₇N₃O₉
Molecular Weight:653.773
Hs Code.:

2-{(R)-3-[(2R,3R,4R)-2,3-Bis-benzyloxy-4-(tert-butoxycarbonyl-methyl-amino)-5-methoxy-pentanoylamino]-1-methyl-propyl}-oxazole-4-carboxylic acid methyl ester

Synonyms:2-{(R)-3-[(2R,3R,4R)-2,3-Bis-benzyloxy-4-(tert-butoxycarbonyl-methyl-amino)-5-methoxy-pentanoylamino]-1-methyl-propyl}-oxazole-4-carboxylic acid methyl ester

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Chemical Property of 2-{(R)-3-[(2R,3R,4R)-2,3-Bis-benzyloxy-4-(tert-butoxycarbonyl-methyl-amino)-5-methoxy-pentanoylamino]-1-methyl-propyl}-oxazole-4-carboxylic acid methyl ester

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Technology Process of 2-{(R)-3-[(2R,3R,4R)-2,3-Bis-benzyloxy-4-(tert-butoxycarbonyl-methyl-amino)-5-methoxy-pentanoylamino]-1-methyl-propyl}-oxazole-4-carboxylic acid methyl ester

There total 14 articles about 2-{(R)-3-[(2R,3R,4R)-2,3-Bis-benzyloxy-4-(tert-butoxycarbonyl-methyl-amino)-5-methoxy-pentanoylamino]-1-methyl-propyl}-oxazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 144681-92-5
methyl 2-(4-amino-(2R)-butyl)-4-oxazolecarboxylate

: 144681-95-8
(2R,3R,4R)-2,3-Bis-benzyloxy-4-(tert-butoxycarbonyl-methyl-amino)-5-methoxy-pentanoic acid

: 144681-93-6
2-{(R)-3-[(2R,3R,4R)-2,3-Bis-benzyloxy-4-(tert-butoxycarbonyl-methyl-amino)-5-methoxy-pentanoylamino]-1-methyl-propyl}-oxazole-4-carboxylic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 25 ℃;
DOI:10.1039/c39920001240

Reference yield:

: 137664-55-2
methyl 2-(4-azido-(2R)-butyl)-4-oxazolecarboxylate

: 144681-93-6
2-{(R)-3-[(2R,3R,4R)-2,3-Bis-benzyloxy-4-(tert-butoxycarbonyl-methyl-amino)-5-methoxy-pentanoylamino]-1-methyl-propyl}-oxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol

2: 78 percent / N-hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / 0 - 25 °C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1039/c39920001240

Reference yield:

: 736129-22-9
(R)-2-Methyl-pent-4-enimidic acid methyl ester

: 144681-93-6
2-{(R)-3-[(2R,3R,4R)-2,3-Bis-benzyloxy-4-(tert-butoxycarbonyl-methyl-amino)-5-methoxy-pentanoylamino]-1-methyl-propyl}-oxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: Et₃N / CH₂Cl₂ / 0 °C

2: 1.) HCl, 2.) Et₃N / 1.) MeOH, 0 deg C, 2.) CH₂Cl₂

3: t-BuOK / diethyl ether

4: AcOH

5: OsO₄, N-methylmorpholine N-oxide / acetone; H₂O

6: NaIO₄ / tetrahydrofuran; H₂O

7: NaBH₄ / methanol / 0 °C

8: Et₃N / CH₂Cl₂

9: NaN₃ / dimethylformamide

10: H₂ / Pd/C / ethanol

11: 78 percent / N-hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / 0 - 25 °C

With hydrogenchloride; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium azide; potassium tert-butylate; hydrogen; benzotriazol-1-ol; acetic acid; 4-methylmorpholine N-oxide; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1039/c39920001240