Technology Process of (6S,7S,8S,Z)-4-ethyliden-6-methoxy-8-{2-[(4-methoxybenzyl)oxy]ethyl}-2,2,5,5,7,10,10,11,11-nonamethyl-3,9-dioxa-2,10-disiladodecane
There total 9 articles about (6S,7S,8S,Z)-4-ethyliden-6-methoxy-8-{2-[(4-methoxybenzyl)oxy]ethyl}-2,2,5,5,7,10,10,11,11-nonamethyl-3,9-dioxa-2,10-disiladodecane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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![(6S,7S,8S,Z)-4-ethyliden-6-methoxy-8-{2-[(4-methoxybenzyl)oxy]ethyl}-2,2,5,5,7,10,10,11,11-nonamethyl-3,9-dioxa-2,10-disiladodecane](/Databaselist/images/loading.webp)
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1268687-87-1
(6S,7S,8S,Z)-4-ethyliden-6-methoxy-8-{2-[(4-methoxybenzyl)oxy]ethyl}-2,2,5,5,7,10,10,11,11-nonamethyl-3,9-dioxa-2,10-disiladodecane
- Guidance literature:
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(5S,6S,7S)-7-[(tert-butyldimethylsilyl)oxy]-5-methoxy-9-[(4-methoxybenzyl)oxy]-4,4,6-trimethylnonan-3-one;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 - -50 ℃;
Inert atmosphere;
With
N,N,N,N,N,N-hexamethylphosphoric triamide;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
Inert atmosphere;
trimethylsilyl trifluoromethanesulfonate;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 6h;
Inert atmosphere;
DOI:10.1002/anie.201005605
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1268687-87-1
(6S,7S,8S,Z)-4-ethyliden-6-methoxy-8-{2-[(4-methoxybenzyl)oxy]ethyl}-2,2,5,5,7,10,10,11,11-nonamethyl-3,9-dioxa-2,10-disiladodecane
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 2,6-dimethylpyridine / dichloromethane / 3 h / -20 - 20 °C
2.1: lithium borohydride / tetrahydrofuran; methanol; diethyl ether / -10 - 0 °C
3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0 - 20 °C
4.1: calcium hydride; boron trifluoride diethyl etherate / dichloromethane / 3 h / -78 °C
5.1: proton sponge / dichloromethane / 48 h / -20 °C
6.1: pentane / 3 h / 0 °C
7.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
7.2: 4 h / -78 - 0 °C
8.1: lithium diisopropyl amide / tetrahydrofuran / -78 - -50 °C / Inert atmosphere
8.2: 0.5 h / -78 °C / Inert atmosphere
8.3: 6 h / -78 - 20 °C / Inert atmosphere
With
2,6-dimethylpyridine; lithium borohydride; calcium hydride; boron trifluoride diethyl etherate; sodium hydrogencarbonate; Dess-Martin periodane; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; pentane;
3.1: Dess-Martin oxidation / 4.1: Mukaiyama reaction;
DOI:10.1002/anie.201005605
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1268687-87-1
(6S,7S,8S,Z)-4-ethyliden-6-methoxy-8-{2-[(4-methoxybenzyl)oxy]ethyl}-2,2,5,5,7,10,10,11,11-nonamethyl-3,9-dioxa-2,10-disiladodecane
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pentane / 3 h / 0 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
2.2: 4 h / -78 - 0 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / -78 - -50 °C / Inert atmosphere
3.2: 0.5 h / -78 °C / Inert atmosphere
3.3: 6 h / -78 - 20 °C / Inert atmosphere
With
lithium diisopropyl amide;
In
tetrahydrofuran; pentane;
DOI:10.1002/anie.201005605
