6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyl ester

Base Information

Chemical Name:6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyl ester
CAS No.:264888-56-4
Molecular Formula:C₃₂H₄₄N₂O₈
Molecular Weight:584.71
Hs Code.:

6-benzyloxycarbonylamino-2-<i>tert</i>-butoxycarbonylamino-hexanoic acid 3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyl ester

Synonyms:6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyl ester

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Chemical Property of 6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyl ester

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Technology Process of 6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyl ester

There total 5 articles about 6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 264888-41-7
6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 3-(3-benzyloxy-6-hydroxy-2,4-dimethyl-phenyl)-3-methyl-butyl ester

: 264888-56-4
6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyl ester

Guidance literature:: With N-Bromosuccinimide; In water; acetone; for 0.25h;
DOI:10.1248/cpb.48.238

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 264888-56-4
6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / DCC; DMAP / CH₂Cl₂ / 20 °C

2: 99 percent / NBS / acetone; H₂O / 0.25 h

With dmap; N-Bromosuccinimide; dicyclohexyl-carbodiimide; In dichloromethane; water; acetone; 1: Acylation / 2: Oxidation;
DOI:10.1248/cpb.48.238

Reference yield:

: 50442-68-7
6-hydroxy-4,4,5,7-tetramethyl-3,4-dihydrocoumarin

: 264888-56-4
6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / K₂CO₃; NaI / acetone / 20 h / Heating

2: 97 percent / LiAlH₄ / tetrahydrofuran / 7 h / 20 °C

3: 85 percent / DCC; DMAP / CH₂Cl₂ / 20 °C

4: 99 percent / NBS / acetone; H₂O / 0.25 h

With dmap; N-Bromosuccinimide; lithium aluminium tetrahydride; potassium carbonate; dicyclohexyl-carbodiimide; sodium iodide; In tetrahydrofuran; dichloromethane; water; acetone; 1: Alkylation / 2: Reduction / 3: Acylation / 4: Oxidation;
DOI:10.1248/cpb.48.238