Technology Process of eudistomidin G
There total 4 articles about eudistomidin G which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux
1.2: 0.5 h / 0 - 20 °C / Saturated solution
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 0 - 20 °C
3.1: trichlorophosphate / benzene / 1.5 h / Reflux
4.1: formic acid; triethylamine / N,N-dimethyl-formamide / 13 h
5.1: sodium cyanoborohydride / acetonitrile / 20 °C
6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 20 °C
With
lithium aluminium tetrahydride; formic acid; sodium cyanoborohydride; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
3.1: Bischler-Napieralski reaction / 4.1: Noyori catalytic asymmetric hydrogen-transfer reaction;
DOI:10.1016/j.tet.2012.05.071
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trichlorophosphate / benzene / 1.5 h / Reflux
2: formic acid; triethylamine / N,N-dimethyl-formamide / 13 h
3: sodium cyanoborohydride / acetonitrile / 20 °C
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 20 °C
With
formic acid; sodium cyanoborohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trichlorophosphate;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
1: Bischler-Napieralski reaction / 2: Noyori catalytic asymmetric hydrogen-transfer reaction;
DOI:10.1016/j.tet.2012.05.071
- Guidance literature:
-
Multi-step reaction with 3 steps
1: formic acid; triethylamine / N,N-dimethyl-formamide / 13 h
2: sodium cyanoborohydride / acetonitrile / 20 °C
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 20 °C
With
formic acid; sodium cyanoborohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile;
1: Noyori catalytic asymmetric hydrogen-transfer reaction;
DOI:10.1016/j.tet.2012.05.071
