ethyl N-{7-[3-(4-fluorophenyl)acetyl-4-methoxyphenoxy]-6-methylindan-4-yl}malonamate

Base Information

Chemical Name:ethyl N-{7-[3-(4-fluorophenyl)acetyl-4-methoxyphenoxy]-6-methylindan-4-yl}malonamate
CAS No.:575505-49-6
Molecular Formula:C₃₀H₃₀FNO₆
Molecular Weight:519.57
Hs Code.:

Synonyms:ethyl N-{7-[3-(4-fluorophenyl)acetyl-4-methoxyphenoxy]-6-methylindan-4-yl}malonamate

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Chemical Property of ethyl N-{7-[3-(4-fluorophenyl)acetyl-4-methoxyphenoxy]-6-methylindan-4-yl}malonamate

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Technology Process of ethyl N-{7-[3-(4-fluorophenyl)acetyl-4-methoxyphenoxy]-6-methylindan-4-yl}malonamate

There total 3 articles about ethyl N-{7-[3-(4-fluorophenyl)acetyl-4-methoxyphenoxy]-6-methylindan-4-yl}malonamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 575505-40-7
ethyl N-[7-(4-methoxyphenoxy)-6-methylindan-4-yl]malonamate

: 405-50-5
p-Fluorophenylacetic acid

: 575505-49-6
ethyl N-{7-[3-(4-fluorophenyl)acetyl-4-methoxyphenoxy]-6-methylindan-4-yl}malonamate

Guidance literature:: With trifluoromethylsulfonic anhydride; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1016/j.bmc.2012.12.002

Reference yield:

: 575505-40-7
ethyl N-[7-(4-methoxyphenoxy)-6-methylindan-4-yl]malonamate

: 7732-18-5
water

: 76-05-1
trifluoroacetic acid

: 575505-49-6
ethyl N-{7-[3-(4-fluorophenyl)acetyl-4-methoxyphenoxy]-6-methylindan-4-yl}malonamate

Guidance literature:: ethyl N-[7-(4-methoxyphenoxy)-6-methylindan-4-yl]malonamate; trifluoroacetic acid; With trifluoromethanesulfonic acid anhydride; In dichloromethane; at 20 ℃; for 15h;

water; In dichloromethane;

Reference yield:

: 575505-01-0
[7-(4-methoxyphenoxy)-6-methylindan-4-yl]amine

: 575505-49-6
ethyl N-{7-[3-(4-fluorophenyl)acetyl-4-methoxyphenoxy]-6-methylindan-4-yl}malonamate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 3 h / 20 °C

2: trifluoromethylsulfonic anhydride / dichloromethane / 15 h / 20 °C

With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; 2: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmc.2012.12.002