<(2R,3S)+(2S,3R)>-N-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

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Chemical Name:<(2R,3S)+(2S,3R)>-N-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide
CAS No.:131541-25-8
Molecular Formula:C₃₆H₄₀ClF₃N₄O₇S
Molecular Weight:765.25
Hs Code.:

<(2R,3S)+(2S,3R)>-N-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

Synonyms:<(2R,3S)+(2S,3R)>-N-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

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Chemical Property of <(2R,3S)+(2S,3R)>-N-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

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Technology Process of <(2R,3S)+(2S,3R)>-N-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

There total 11 articles about <(2R,3S)+(2S,3R)>-N-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 105080-63-5
4-[(4-Chlorophenyl)sulfonylaminocarbonyl] benzene carboxylic acid

: 131506-13-3
<(32R,3S)+(2S,3R)>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

: 131541-25-8
<(2R,3S)+(2S,3R)>-N-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; for 4.5h;
DOI:10.1021/jm00082a005

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 131541-25-8
<(2R,3S)+(2S,3R)>-N-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

Guidance literature:: Multi-step reaction with 5 steps

1: DMAP, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / CH₂Cl₂ / 16 h / Ambient temperature

2: 1 aq. KOH / ethanol / 16 h / Ambient temperature

3: 1.) CDI, 2.) Et₃N / 1.) CH₂Cl₂, RT, 2 h, 2.) CH₂Cl₂, 16 h

4: H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

5: 80 percent / HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

With dmap; potassium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00082a005

Reference yield:

: 80871-69-8
N-(2,3-dihydro-1H-inden-2-yl)glycine ethyl ester hydrochloride

: 131541-25-8
<(2R,3S)+(2S,3R)>-N-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

Guidance literature:: Multi-step reaction with 5 steps

1: DMAP, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / CH₂Cl₂ / 16 h / Ambient temperature

2: 1 aq. KOH / ethanol / 16 h / Ambient temperature

3: 1.) CDI, 2.) Et₃N / 1.) CH₂Cl₂, RT, 2 h, 2.) CH₂Cl₂, 16 h

4: H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

5: 80 percent / HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

With dmap; potassium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00082a005